Deriglidole | CAS# 122830-14-2 | alpha2-adrenoceptor antagonist

MedKoo Cat#: 413550 | Name: Deriglidole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Deriglidole is a selective peripheral alpha2-adrenoceptor antagonist.

Chemical Structure

Deriglidole

CAS#122830-14-2

Theoretical Analysis

MedKoo Cat#: 413550

Name: Deriglidole

CAS#: 122830-14-2

Chemical Formula: C16H21N3

Exact Mass: 255.1735

Molecular Weight: 255.37

Elemental Analysis: C, 75.26; H, 8.29; N, 16.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Deriglidole; UNII-68EP8R4PMV

IUPAC/Chemical Name

(+)-1,2,4,5-Tetrahydro-2-(2-imidazolin-2-yl)-2-propylpyrrolo(3,2,1-hi)indole

InChi Key

BADQRNHAZHSOKC-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H21N3/c1-2-7-16(15-17-8-9-18-15)11-13-5-3-4-12-6-10-19(16)14(12)13/h3-5H,2,6-11H2,1H3,(H,17,18)

SMILES Code

CCCC1(C2=NCCN2)N3C4=C(C=CC=C4CC3)C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 255.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Guillot E, Coste A, Eon MT, Angel I. Mechanisms of the hypoglycemic effects of the alpha2-adrenoceptor antagonists SL84.0418 and deriglidole. Life Sci. 1998;62(9):839-52. doi: 10.1016/s0024-3205(97)01186-7. PMID: 9496702. 2: Natali A, Gastaldelli A, Galvan AQ, Sironi AM, Ciociaro D, Sanna G, Rosenzweig P, Ferrannini E. Effects of acute alpha 2-blockade on insulin action and secretion in humans. Am J Physiol. 1998 Jan;274(1):E57-64. doi: 10.1152/ajpendo.1998.274.1.E57. PMID: 9458748. 3: Guillot E, Coste A, Angel I. Involvement of capsaicin-sensitive nerves in the regulation of glucose tolerance in diabetic rats. Life Sci. 1996;59(12):969-77. doi: 10.1016/0024-3205(96)00403-1. PMID: 8809210. 4: Jonas JC, Garcia-Barrado MJ, Angel I, Henquin JC. The imidazoline SL 84.0418 shows stereoselectivity in blocking alpha 2-adrenoceptors but not ATP-sensitive K+ channels in pancreatic B-cells. Eur J Pharmacol. 1994 Oct 13;264(1):81-4. doi: 10.1016/0014-2999(94)90639-4. PMID: 7828647. 5: Guillot E, Morand R, Bouloy C, Eon MT, Angel I. Involvement of alpha 2-adrenoceptors in metabolic and hormonal responses to a mixed meal in beagle dogs. Am J Physiol. 1995 Dec;269(6 Pt 1):E991-5. doi: 10.1152/ajpendo.1995.269.6.E991. PMID: 8572207. 6: Guillot E, Coste A, Angel I. Alpha 2-adrenoceptors and the regulation of glucose, insulin and amylin levels in diabetic rats. Life Sci. 1995;57(23):2081-90. doi: 10.1016/0024-3205(95)02201-s. PMID: 7475961.