OVN73571 | Fmoc-Ser(GalNAc(Ac)3-alpha-D)-OH | CAS#120173-57-1 | Synthetic intermediate

MedKoo Cat#: 555926 | Name: OVN73571

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OVN73571, also known as Fmoc-Ser[GalNAc(Ac)3-α-D]-OH, is a useful chemical intermediate for synthesis of Tn/T Antigen MUC1 Glycopeptide BSA Conjugates, which can use used as Vaccines. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

OVN73571

CAS#120173-57-1

Theoretical Analysis

MedKoo Cat#: 555926

Name: OVN73571

CAS#: 120173-57-1

Chemical Formula: C32H36N2O13

Exact Mass: 656.2217

Molecular Weight: 656.64

Elemental Analysis: C, 58.53; H, 5.53; N, 4.27; O, 31.67

Price and Availability

Size	Price	Availability
10mg	USD 250.00	2 Weeks
25mg	USD 450.00	2 Weeks
50mg	USD 750.00	2 Weeks
100mg	USD 1,350.00	2 Weeks
200mg	USD 2,350.00	2 Weeks
500mg	USD 3,950.00	2 Weeks

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Related CAS #

No Data

Synonym

Fmoc-L-Ser(alpha-D-GalNAc(Ac)3)-OH; Fmoc-Ser(GalNAc(Ac)3-alpha-D)-OH; Fmoc-Ser(O-|A-D-GalNAc(OAc)3)-OH; Fmoc-Ser(GalNAc(Ac)-D)-OH; OVN73571; OVN-73571; OVN 73571;

IUPAC/Chemical Name

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-serine

InChi Key

ORICVOOXZDVFIP-VOZJJELXSA-N

InChi Code

InChI=1S/C32H36N2O13/c1-16(35)33-27-29(46-19(4)38)28(45-18(3)37)26(15-42-17(2)36)47-31(27)43-14-25(30(39)40)34-32(41)44-13-24-22-11-7-5-9-20(22)21-10-6-8-12-23(21)24/h5-12,24-29,31H,13-15H2,1-4H3,(H,33,35)(H,34,41)(H,39,40)/t25-,26+,27+,28-,29+,31-/m0/s1

SMILES Code

O=C(O)[C@H](CO[C@@H]1[C@H](NC(C)=O)[C@H]([C@H]([C@@H](COC(C)=O)O1)OC(C)=O)OC(C)=O)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Appearance

Purity

>97% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

A MUC1 anticancer vaccine equipped with covalently linked divalent mannose ligands was found to improve the antigen uptake and presentation by targeting mannose-receptor-pos. macrophages and dendritic cells. It induced much stronger specific IgG immune responses in mice than the non-mannosylated ref. vaccine. Mannose coupling also led to increased nos. of macrophages, dendritic cells, and CD4+ T cells in the local lymph organs. Comparison of di- and tetravalent mannose ligands revealed an increased binding of the tetravalent version, suggesting that higher valency improves binding to the mannose receptor. The mannose-coupled vaccine and the non-mannosylated ref. vaccine induced IgG antibodies that exhibited similar binding to human breast tumor cells.

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	To be determined	0.0	0.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 656.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Eberling J, Braun P, Kowalczyk D, Schultz M, Kunz H. Chemoselective Removal of Protecting Groups from O-Glycosyl Amino Acid and Peptide (Methoxyethoxy)ethyl Esters Using Lipases and Papain. J Org Chem. 1996 Apr 19;61(8):2638-2646. doi: 10.1021/jo951899j. PMID: 11667093.