Asarone | CAS#2883-98-9 | Medicinal herb component

MedKoo Cat#: 464255 | Name: Asarone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Asarone (α-Asarone) is an effective component isolated from the chinese medicinal herb Acorus tatarinowii. It is clinically used as medication for treating epilepsy, cough, bronchitis and asthma. It exhibits neuroprotective, anti-oxidative, anticonvulsive and cognitive enhancing action.

Chemical Structure

Asarone

CAS#2883-98-9

Theoretical Analysis

MedKoo Cat#: 464255

Name: Asarone

CAS#: 2883-98-9

Chemical Formula: C12H16O3

Exact Mass: 208.1099

Molecular Weight: 208.26

Elemental Analysis: C, 69.21; H, 7.74; O, 23.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Asarone; Asaron; Etherophenol; α-Asarone;

IUPAC/Chemical Name

(E)-1,2,4-trimethoxy-5-(prop-1-en-1-yl)benzene

InChi Key

RKFAZBXYICVSKP-AATRIKPKSA-N

InChi Code

InChI=1S/C12H16O3/c1-5-6-9-7-11(14-3)12(15-4)8-10(9)13-2/h5-8H,1-4H3/b6-5+

SMILES Code

COc1c(OC)cc(/C=C/C)c(OC)c1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	To be determined	0.0	0.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 208.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mikami M, Takuya O, Yoshino Y, Nakamura S, Ito K, Kojima H, Takahashi T, Iddamalgoda A, Inoue S, Shimazawa M, Hara H. Acorus calamus extract and its component α-asarone attenuate murine hippocampal neuronal cell death induced by l-glutamate and tunicamycin. Biosci Biotechnol Biochem. 2021 Feb 24;85(3):493-501. doi: 10.1093/bbb/zbaa071. PMID: 33589895. 2: Zhang T, Wang J, Shen BD, Zhu JJ, Wang LQ, Yuan HL. [Preparation and in vitro quality evaluation of self-microemulsion co-loaded with tenuifolin and β-asarone]. Zhongguo Zhong Yao Za Zhi. 2020 Dec;45(24):5988-5995. Chinese. doi: 10.19540/j.cnki.cjcmm.20200922.301. PMID: 33496139. 3: Xu X, Li X, Liu Z, Wang F, Fan L, Wu C, Yao Y. Knockdown of CYP301B1 and CYP6AX1v2 increases the susceptibility of the brown planthopper to beta-asarone, a potential plant-derived insecticide. Int J Biol Macromol. 2021 Feb 28;171:150-157. doi: 10.1016/j.ijbiomac.2020.12.217. Epub 2021 Jan 5. PMID: 33418039. 4: Zeng L, Zhang D, Liu Q, Zhang J, Mu K, Gao X, Zhang K, Li H, Wang Q, Zheng Y, Mao S. Alpha-asarone Improves Cognitive Function of APP/PS1 Mice and Reducing Aβ42, P-tau and Neuroinflammation, and Promoting Neuron Survival in the Hippocampus. Neuroscience. 2021 Mar 15;458:141-152. doi: 10.1016/j.neuroscience.2020.12.026. Epub 2021 Jan 5. PMID: 33412244. 5: Hermes L, Römermann J, Cramer B, Esselen M. Quantitative Analysis of β-Asarone Derivatives in Acorus calamus and Herbal Food Products by HPLC- MS/MS. J Agric Food Chem. 2021 Jan 20;69(2):776-782. doi: 10.1021/acs.jafc.0c05513. Epub 2021 Jan 7. PMID: 33410326. 6: Zhang Y, Long Y, Yu S, Li D, Yang M, Guan Y, Zhang D, Wan J, Liu S, Shi A, Li N, Peng W. Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder. Pharmacol Res. 2021 Feb;164:105376. doi: 10.1016/j.phrs.2020.105376. Epub 2020 Dec 11. PMID: 33316383. 7: Uebel T, Hermes L, Haupenthal S, Müller L, Esselen M. α-Asarone, β-asarone, and γ-asarone: Current status of toxicological evaluation. J Appl Toxicol. 2020 Nov 25. doi: 10.1002/jat.4112. Epub ahead of print. PMID: 33236787. 8: Liu F, Zhao Q, Liu S, Xu Y, Zhou D, Gao Y, Zhu L. Revealing the Pharmacological Mechanism of Acorus tatarinowii in the Treatment of Ischemic Stroke Based on Network Pharmacology. Evid Based Complement Alternat Med. 2020 Oct 31;2020:3236768. doi: 10.1155/2020/3236768. PMID: 33178313; PMCID: PMC7648688. 9: Zhu MJ, Mao ZH, Guo HY, Zhu HZ, Ding XM. [Effects of acorus tatarinowii Schott and alpha asarone on free radicals and nNOS/NO in hippocampus of rats with fatigue movement]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Jul;36(4):306-311. Chinese. doi: 10.12047/j.cjap.5947.2020.066. PMID: 33167088. 10: Saldanha AA, Vieira L, Maia DSDS, de Oliveira FM, Ribeiro RIMA, Thomé RG, Dos Santos HB, Lopes DO, Carollo CA, Silva DB, Soares AC, de Siqueira JM. Anti- inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea. Inflammopharmacology. 2020 Nov 6. doi: 10.1007/s10787-020-00775-7. Epub ahead of print. PMID: 33156477. 11: Ramalingam P, Ganesan P, Prabakaran DS, Gupta PK, Jonnalagadda S, Govindarajan K, Vishnu R, Sivalingam K, Sodha S, Choi DK, Ko YT. Lipid Nanoparticles Improve the Uptake of α-Asarone Into the Brain Parenchyma: Formulation, Characterization, In Vivo Pharmacokinetics, and Brain Delivery. AAPS PharmSciTech. 2020 Nov 2;21(8):299. doi: 10.1208/s12249-020-01832-8. PMID: 33140227. 12: Picardo M, Sanchís J, Núñez O, Farré M. Suspect screening of natural toxins in surface and drinking water by high performance liquid chromatography and high-resolution mass spectrometry. Chemosphere. 2020 Dec;261:127888. doi: 10.1016/j.chemosphere.2020.127888. Epub 2020 Aug 21. PMID: 33113669. 13: Cruz-Cerino P, Cristóbal-Alejo J, Ruiz-Carrera V, Carnevali G, Vera-Ku M, Martín J, Reyes F, Gamboa-Angulo M. Extracts from Six Native Plants of the Yucatán Peninsula Hinder Mycelial Growth of Fusarium equiseti and F. oxysporum, Pathogens of Capsicum chinense. Pathogens. 2020 Oct 10;9(10):827. doi: 10.3390/pathogens9100827. PMID: 33050398; PMCID: PMC7601340. 14: Verma R, Kumar D, Nagraik R, Sharma A, Tapwal A, Puri S, Kumar H, Kumari A, Nepovimova E, Kuca K. Mycorrhizal inoculation impact on Acorus calamus L. - An ethnomedicinal plant of western Himalaya and its in silico studies for anti- inflammatory potential. J Ethnopharmacol. 2021 Jan 30;265:113353. doi: 10.1016/j.jep.2020.113353. Epub 2020 Sep 4. PMID: 32891818. 15: Yan L, Liu Z, Xu L, Qian Y, Song P, Wei M. Identification of volatile active components in Acori Tatarinowii Rhizome essential oil from different regions in China by C6 glioma cells. BMC Complement Med Ther. 2020 Aug 17;20(1):255. doi: 10.1186/s12906-020-03020-4. PMID: 32807141; PMCID: PMC7430108. 16: Wang ZJ, Zhu YY, Yi X, Zhou ZS, He YJ, Zhou Y, Qi ZH, Jin DN, Zhao LX, Luo XD. Bioguided isolation, identification and activity evaluation of antifungal compounds from Acorus tatarinowii Schott. J Ethnopharmacol. 2020 Oct 28;261:113119. doi: 10.1016/j.jep.2020.113119. Epub 2020 Jul 15. PMID: 32679258. 17: Hei X, Xie M, Xu J, Li J, Liu T. β-Asarone Exerts Antioxidative Effects on H2O2-Stimulated PC12 Cells by Activating Nrf2/HO-1 Pathway. Neurochem Res. 2020 Aug;45(8):1953-1961. doi: 10.1007/s11064-020-03060-9. Epub 2020 Jul 4. PMID: 32623664. 18: Maia DS, Lopes CF, Saldanha AA, Silva NL, Sartori ÂLB, Carollo CA, Sobral MG, Alves SN, Silva DB, de Siqueira JM. Larvicidal effect from different Annonaceae species on Culex quinquefasciatus. Environ Sci Pollut Res Int. 2020 Oct;27(29):36983-36993. doi: 10.1007/s11356-020-08997-6. Epub 2020 Jun 23. PMID: 32577964. 19: Liang X, Liu CS, Xia T, Tang QF, Tan XM. Identification of Active Compounds of Mahuang Fuzi Xixin Decoction and Their Mechanisms of Action by LC-MS/MS and Network Pharmacology. Evid Based Complement Alternat Med. 2020 May 23;2020:3812180. doi: 10.1155/2020/3812180. PMID: 32565854; PMCID: PMC7267872. 20: Han Y, Wang N, Kang J, Fang Y. β-Asarone improves learning and memory in Aβ1-42-induced Alzheimer's disease rats by regulating PINK1-Parkin- mediated mitophagy. Metab Brain Dis. 2020 Oct;35(7):1109-1117. doi: 10.1007/s11011-020-00587-2. Epub 2020 Jun 18. PMID: 32556928.