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MedKoo Cat#: 413533 | Name: Dentatin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dentatin is a member of coumarins. It has a role as a metabolite with research it on how it effects prostate cancer

Chemical Structure

Dentatin
Dentatin
CAS#22980-57-0

Theoretical Analysis

MedKoo Cat#: 413533

Name: Dentatin

CAS#: 22980-57-0

Chemical Formula: C20H22O4

Exact Mass: 326.1518

Molecular Weight: 326.39

Elemental Analysis: C, 73.60; H, 6.79; O, 19.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Dentatin; NSC380684; NSC-380684; NSC 380684
IUPAC/Chemical Name
10-(1,1-Dimethyl-allyl)-5-methoxy-8,8-dimethyl-8H-pyrano(3,2-g)chromen-2-one
InChi Key
QBFYQVZGIDUNIY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H22O4/c1-7-19(2,3)15-17-12(8-9-14(21)23-17)16(22-6)13-10-11-20(4,5)24-18(13)15/h7-11H,1H2,2-6H3
SMILES Code
O=C1C=CC2=C(O1)C(C(C)(C)C=C)=C3C(C=CC(C)(C)O3)=C2OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 326.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xiong W, Dong J, Kong S. Dentatin exerts anticancer effects on human colon cancer cell lines via cell cycle arrest, autophagy, inhibition of cell migration and JAK/STAT signalling pathway. J BUON. 2019 Jul-Aug;24(4):1488-1493. PMID: 31646796. 2: Sidahmed HMA, Vadivelu J, Loke MF, Arbab IA, Abdul B, Sukari MA, Abdelwahab SI. Anti-ulcerogenic activity of dentatin from clausena excavata Burm.f. against ethanol-induced gastric ulcer in rats: Possible role of mucus and anti-oxidant effect. Phytomedicine. 2019 Mar 1;55:31-39. doi: 10.1016/j.phymed.2018.06.036. Epub 2018 Aug 3. PMID: 30668441. 3: Andas AR, Abdul AB, Rahman HS, Sukari MA, Abdelwahab SI, Samad NA, Anasamy T, Arbab IA. Dentatin from Clausena excavata Induces Apoptosis in HepG2 Cells via Mitochondrial Mediated Signaling. Asian Pac J Cancer Prev. 2015;16(10):4311-6. doi: 10.7314/apjcp.2015.16.10.4311. PMID: 26028091. 4: Al-Abboodi AS, Rasedee A, Abdul AB, Taufiq-Yap YH, Alkaby WAA, Ghaji MS, Waziri PM, Al-Qubaisi MS. Anticancer effect of dentatin and dentatin- hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line. Drug Des Devel Ther. 2017 Nov 23;11:3309-3319. doi: 10.2147/DDDT.S147626. PMID: 29200826; PMCID: PMC5703156. 5: Arbab IA, Looi CY, Abdul AB, Cheah FK, Wong WF, Sukari MA, Abdullah R, Mohan S, Syam S, Arya A, Mohamed Elhassan Taha M, Muharram B, Rais Mustafa M, Ibrahim Abdelwahab S. Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition. Evid Based Complement Alternat Med. 2012;2012:856029. doi: 10.1155/2012/856029. Epub 2012 Oct 3. PMID: 23091559; PMCID: PMC3471446. 6: Arbab IA, Abdul AB, Sukari MA, Abdullah R, Syam S, Kamalidehghan B, Ibrahim MY, Taha MM, Abdelwahab SI, Ali HM, Mohan S. Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-κB signalling and G0/G1 cell cycle arrest: a bioassay-guided approach. J Ethnopharmacol. 2013 Jan 9;145(1):343-54. doi: 10.1016/j.jep.2012.11.020. Epub 2012 Nov 23. PMID: 23178663. 7: Quan NV, Xuan TD, Anh H, Tran HD. Bio-Guided Isolation of Prospective Bioactive Constituents from Roots of Clausena indica (Dalzell) Oliv. Molecules. 2019 Dec 4;24(24):4442. doi: 10.3390/molecules24244442. PMID: 31817276; PMCID: PMC6943736. 8: Jantamat P, Weerapreeyakul N, Puthongking P. Cytotoxicity and Apoptosis Induction of Coumarins and Carbazole Alkaloids from Clausena harmandiana. Molecules. 2019 Sep 18;24(18):3385. doi: 10.3390/molecules24183385. PMID: 31540345; PMCID: PMC6767265. 9: Ashwaq AS, Al-Qubaisi MS, Rasedee A, Abdul AB, Taufiq-Yap YH, Yeap SK. Inducing G2/M Cell Cycle Arrest and Apoptosis through Generation Reactive Oxygen Species (ROS)-Mediated Mitochondria Pathway in HT-29 Cells by Dentatin (DEN) and Dentatin Incorporated in Hydroxypropyl-β-Cyclodextrin (DEN-HPβCD). Int J Mol Sci. 2016 Oct 18;17(10):1653. doi: 10.3390/ijms17101653. PMID: 27763535; PMCID: PMC5085686. 10: Hoang Anh L, Xuan TD, Dieu Thuy NT, Quan NV, Trang LT. Antioxidant and a-amylase Inhibitory Activities and Phytocompounds of Clausena indica Fruits. Medicines (Basel). 2020 Feb 28;7(3):10. doi: 10.3390/medicines7030010. PMID: 32121132; PMCID: PMC7151626.