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MedKoo Cat#: 413532 | Name: Denotivir

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Denotivir is an isothiazole derivative of 5-amino-3-methylisothiazolocarboxylic acid I with antiviral activity against human herpes simplex viruse types 1 and 2, and varicella zoster virus.

Chemical Structure

Denotivir
Denotivir
CAS#51287-57-1

Theoretical Analysis

MedKoo Cat#: 413532

Name: Denotivir

CAS#: 51287-57-1

Chemical Formula: C18H14ClN3O2S

Exact Mass: 371.0495

Molecular Weight: 371.84

Elemental Analysis: C, 58.14; H, 3.80; Cl, 9.53; N, 11.30; O, 8.61; S, 8.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Denotivir; T15; T 15; T-15
IUPAC/Chemical Name
4-Isothiazolecarboxamide, 5-(benzoylamino)-N-(p-chlorophenyl)-3-methyl-
InChi Key
ZPBLNADJHWHOEP-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H14ClN3O2S/c1-11-15(17(24)20-14-9-7-13(19)8-10-14)18(25-22-11)21-16(23)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,24)(H,21,23)
SMILES Code
O=C(C1=C(NC(C2=CC=CC=C2)=O)SN=C1C)NC3=CC=C(Cl)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 371.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Machoń Z, Wieczorek Z, Zimecki M. Immunotropic activity of vratizolin (ITCL, Denotivir). Pol J Pharmacol. 2001 Jul-Aug;53(4):377-83. PMID: 11990084. 2: Godlewska M, Zgoda MM. Release of denotivir from the dispersed systems. Part I. Properties of hydrogel vehiculum and availability of active substance from intravaginal form of drug. Acta Pol Pharm. 1996 Nov-Dec;53(6):403-10. PMID: 9415215. 3: Regiec A, Machoń Z, Miedzybrodzki R, Szymaniec S. New isothiazole derivatives: synthesis, reactivity, physicochemical properties and pharmacological activity. Arch Pharm (Weinheim). 2006 Jul;339(7):401-13. doi: 10.1002/ardp.200500040. PMID: 16838283. 4: Daidone G, Plescia F, Maggio B, Raffa D, Cutuli VM, Mangano NG, Caruso A. Phenylamides of 1-phenyl (or methyl)-5-benzamidopyrazole-4-carboxylic acid as vratizolin analogs with analgesic and antiinflammatory activities. Arch Pharm (Weinheim). 2001 May;334(5):153-6. doi: 10.1002/1521-4184(200105)334:5<153::aid- ardp153>3.0.co;2-7. PMID: 11413820.

View History

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