DC-K2in212 is a novel potent CDK2 inhibitor with selectivities above 10-fold over CDK1/4/6/7/9/12 above 10-fold, displaying anti-proliferative activity against A2058 melanoma and MV4-11 leukemia cell lines and low toxicity on human normal cell lines, inhibiting CDK2-medieated phosphorylation of Rb, blocking cell cycle progression, and inducing apoptosis.
MedKoo Cat#: 464238
Name: DC-K2in212
CAS#: unknown
Chemical Formula: C23H15F3N6O3
Exact Mass: 480.1158
Molecular Weight: 480.41
Elemental Analysis: C, 57.50; H, 3.15; F, 11.86; N, 17.49; O, 9.99
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| To be determined | 0.0 | 0.00 |
The following data is based on the product molecular weight 480.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
