MedKoo Cat#: 464231 | Name: Quinaldine blue
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quinaldine blue is a cyanine dye. It is an organic cation, typically isolated as the chloride or iodide salts. The blue dye is prepared from 2-methylquinoline by quaternization with ethyl chloride or ethyl iodide. Condensation with formaldehyde results in coupling. Subsequent oxidation of the leuco intermediate gives the dye. Quinaldine blue is a prototypical cyanine dye that was widely used as a sensitizer in electrophotography. Its biological properties have also been investigated widely.

Chemical Structure

Quinaldine blue
Quinaldine blue
CAS#2768-90-3

Theoretical Analysis

MedKoo Cat#: 464231

Name: Quinaldine blue

CAS#: 2768-90-3

Chemical Formula: C25H25ClN2

Exact Mass: 388.1706

Molecular Weight: 388.94

Elemental Analysis: C, 77.20; H, 6.48; Cl, 9.11; N, 7.20

Price and Availability

Size Price Availability Quantity
250mg USD 450.00 2 Weeks
1g USD 750.00 2 Weeks
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Related CAS #
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Synonym
Quinaldine blue; NSC 56808; NSC56808; NSC-56808; Pinacyanol chloride;
IUPAC/Chemical Name
1-ethyl-2-((E)-3-((E)-1-ethylquinolin-2(1H)-ylidene)prop-1-en-1-yl)quinolin-1-ium chloride
InChi Key
FVMNARAKYNRZID-UHFFFAOYSA-M
InChi Code
InChI=1S/C25H25N2.ClH/c1-3-26-22(18-16-20-10-5-7-14-24(20)26)12-9-13-23-19-17-21-11-6-8-15-25(21)27(23)4-2;/h5-19H,3-4H2,1-2H3;1H/q+1;/p-1
SMILES Code
CCN1/C(C=Cc2c1cccc2)=C/C=C/c(cc3)[n+](CC)c4c3cccc4.[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
TBD
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Quinaldine blue is a fluorescent cationic cyanine dye used to stain biological specimens.
In vitro activity:
To identify potential new treatment options for MRSA infections, this study screened a clinical compound library consisting of 1524 compounds using a growth inhibition assay in 96-well plates. They identified 9 new drug candidates, one of which is quinaldine blue and is used for treating parasitic diseases or cancer.
In vivo activity:
Several properties of NaDC-Lip containing HMM (HMM NaDC-Lip), such as particle size, entrapment efficiency, quinaldine blue spectral characteristics, as well as the vesicle stability measurements with calcein were evaluated. In vivo, the area under the plasma concentration-time curve obtained from the pharmacokinetics study of HMM NaDC-Lip was found to be approximately 9.76- and 1.21-fold higher than that of HMM solution and HMM Lip, respectively, indicating that NaDC-Lip can be used as a potential carrier for oral drug administration. Reference: Drug Deliv. 2010 Apr;17(3):164-70. https://pubmed.ncbi.nlm.nih.gov/20196698/
Solvent mg/mL mM
Solubility
TBD 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 388.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Niu H, Yee R, Cui P, Tian L, Zhang S, Shi W, Sullivan D, Zhu B, Zhang W, Zhang Y. Identification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library. Pathogens. 2017 Sep 20;6(3):44. doi: 10.3390/pathogens6030044. PMID: 28930155; PMCID: PMC5618001. 2. Iwamoto Y, Murakami K, Danno M, Tsuchiya M, Masuzawa T, Shimizu T, Morita T, Yanagihara Y. Singlet oxygen production and photobiological effects of pinacyanol chloride on yeast Saccharomyces cerevisiae. J Pharmacobiodyn. 1990 May;13(5):316-20. doi: 10.1248/bpb1978.13.316. PMID: 2177107. 3. Sun J, Deng Y, Wang S, Cao J, Gao X, Dong X. Liposomes incorporating sodium deoxycholate for hexamethylmelamine (HMM) oral delivery: development, characterization, and in vivo evaluation. Drug Deliv. 2010 Apr;17(3):164-70. doi: 10.3109/10717541003667764. PMID: 20196698.
In vitro protocol:
1. Niu H, Yee R, Cui P, Tian L, Zhang S, Shi W, Sullivan D, Zhu B, Zhang W, Zhang Y. Identification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library. Pathogens. 2017 Sep 20;6(3):44. doi: 10.3390/pathogens6030044. PMID: 28930155; PMCID: PMC5618001. 2. Iwamoto Y, Murakami K, Danno M, Tsuchiya M, Masuzawa T, Shimizu T, Morita T, Yanagihara Y. Singlet oxygen production and photobiological effects of pinacyanol chloride on yeast Saccharomyces cerevisiae. J Pharmacobiodyn. 1990 May;13(5):316-20. doi: 10.1248/bpb1978.13.316. PMID: 2177107.
In vivo protocol:
1. Sun J, Deng Y, Wang S, Cao J, Gao X, Dong X. Liposomes incorporating sodium deoxycholate for hexamethylmelamine (HMM) oral delivery: development, characterization, and in vivo evaluation. Drug Deliv. 2010 Apr;17(3):164-70. doi: 10.3109/10717541003667764. PMID: 20196698.
1: Vazquez-Duhalt R, Semple KM, Westlake DW, Fedorak PM. Effect of water- miscible organic solvents on the catalytic activity of cytochrome c. Enzyme Microb Technol. 1993 Nov;15(11):936-43. doi: 10.1016/0141-0229(93)90169-3. PMID: 7764253. 2: Niu H, Yee R, Cui P, Tian L, Zhang S, Shi W, Sullivan D, Zhu B, Zhang W, Zhang Y. Identification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library. Pathogens. 2017 Sep 20;6(3):44. doi: 10.3390/pathogens6030044. PMID: 28930155; PMCID: PMC5618001.