Synonym
Dimefline HCl; Dimefline hydrochloride; NSC 114650; NSC114650; NSC-114650; DW 62; DW62; DW-62; Remeflin; Remefline;
IUPAC/Chemical Name
1-(7-methoxy-3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)-N,N-dimethylmethanaminium chloride
InChi Key
RCISIXJGNBXXPZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21NO3.ClH/c1-13-18(22)15-10-11-17(23-4)16(12-21(2)3)20(15)24-19(13)14-8-6-5-7-9-14;/h5-11H,12H2,1-4H3;1H
SMILES Code
COc1c(C[NH+](C)C)c2c(C(C(C)=C(c3ccccc3)O2)=O)cc1.[Cl-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| To be determined |
0.0 |
0.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
359.85
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Pérez JC. Quelques analeptiques: Rimefline dans leur application clinique [On analeptics: Remeflin and its clinical application]. Hospital (Rio J). 1969 Jun;75(6):2031-5. French. PMID: 4393870.
2: Fossati C. Sulla terapia della insufficienza respiratoria nella tubercolosi polmonare cronica. Impiego degli analettici in generale e del Remeflin in particolare [On the therapy of respiratory insufficiency in chronic pulmonary tuberculosis. Use of analeptics in general and specially of remeflin]. G Ital Mal Torace. 1967 Nov-Dec;21(6):120-9. Italian. PMID: 4389536.
3: Di Maria A. Terapia dell'insufficienza respiratoria con particolare riguardo ad un nuovo analettico: il Remeflin [Therapy of respiratory insufficiency with special reference to a new analeptic: Remeflin]. Minerva Med. 1967 Jun 20;58(49):2291-5. Italian. PMID: 4382087.
4: Di Maria A. Azione bradicardizzante, coronaro-dilatatrice ed antidispnoica del Remeflin in ammalati con insufficienza cardiorespiratoria [Bradycardiac, coronary-dilating and anti-dyspneic action of Remeflin in patients with cardio- respiratory insufficiency]. Minerva Med. 1967 May 9;58(37):1750-3. Italian. PMID: 4381754.
5: Hórai Z, Komeda H, Matsumoto M, Uchihara H, Yoshida S. [Results of clinical trials of Remeflin for chronic respiratory tract diseases]. Nihon Rinsho. 1966 Sep;24(9):1705-8. Japanese. PMID: 6009124.
6: Tuvo F, Battistin L, Russo A, Bouquet F, Balestra F. L'attivazione del tracciato EEG con remeflin, iperpnea e gardenale associati. Studio elettroclinico di 125 casi [Activation of the EEG tracing with combined remeflin, hyperpnea and gardenal. Electroclinical study of 125 cases]. Riv Sper Freniatr Med Leg Alien Ment. 1966 Jun 30;90(3):681-99. Italian. PMID: 4384744.
7: Angelino PF, Gaida A, Dulbecco A. Rilievi di fisiopatologia e clinica nella insufficienza respiratoria cronica prima e dopo somministrazione di Remeflin [Physiopathological and clinical observations on respiratory insufficiency before and after administration of Remeflin]. G Clin Med. 1966 Jun;47(6):554-87. Italian. PMID: 4381463.
8: Sartorelli E, Zedda S. Basi fisiopatologiche dell'impiego del Remeflin nella terapia dell'insufficienza respiratoria nei pneumopazienti [Physiopathologic basis of the use of Remeflin in the treatment of respiratory insufficiency in pulmonary diseases]. G Clin Med. 1966 Jun;47(6):483-509. Italian. PMID: 4381462.
9: Waddell J, Emerson PA. Demefline ('remeflin')--a new respiratory stimulant drug. Curr Ther Res Clin Exp. 1966 Jun;8(6):312-5. PMID: 4379790.
10: Stuart C, Cittadini G, Tomiselli G. La risposta alla panirradiazione del topo pretrattato con farmaci ad azione stimolante generica sul S. N. C. (cardiazol, remeflin) [Panirradiation response of the mouse pretreated with drugs with a generic stimulating action on the central nervous system (cardiazol, remeflin)]. Minerva Radiol. 1965 Oct;10(10):445-8. Italian. PMID: 5857134.
11: Ohno K. [Studies on respiratory stimulation by remeflin. (2. Clinical experiences)]. Masui. 1965 Jan;14(1):45-50. Japanese. PMID: 5898416.
12: ZAFFIRI O, GAZZANO AM. IL REMEFLIN IN ANESTESIA GERIATRICA [REMEFLIN GERIATRIC ANESTHESIA]. Minerva Anestesiol. 1963 Aug;29:309-11. Italian. PMID: 14083374.
13: CUCCODORO GL, CHISTONI GC, ZAPPOLI R. MEGIMIDE, REMEFLIN E STIMOLAZIONE LUMINOSA INTERMITTENTE: CONFRONTO DELLA LORO AZIONE ATTIVANTE SULL'ELETTROENCEFALOGRAMMA DI SOGGETTI EPILETTICI [MEGEMIDE, REMEFLIN AND INTERMITTENT LIGHT STIMULATION: COMPARISON OF THEIR ACTIVATING ACTION ON THE ELECTROENCEPHALOGRAMS OF EPILEPTIC SUBJECTS]. Riv Neurol. 1963 May-Jun;33:240-8. Italian. PMID: 14080270.
14: ALETTI L, BILLIA P, FERRARA L, VIDILI F. [On the action and properties of 3-methyl-7-methoxy-8-dimethyl-aminomethyl-flavone (Remeflin), a new synthetic analeptic]. Minerva Med. 1962 Nov 3;53:3284-92. Italian. PMID: 14011930.
15: SETNIKAR I. [Comparison of the pneumokinetic activity of Remeflin with that of other respiratory stimulants]. Boll Soc Ital Biol Sper. 1961 Dec 31;37:1427-9. Italian. PMID: 13988206.
16: ZAFFIRI O, MENESINI R. [On the prevention of postoperative complications of the respiratory system with Remeflin]. Minerva Anestesiol. 1961 Dec;27:498-502. Italian. PMID: 14009564.
