HCT-13 | CAS#unknown | Copper-dependent cytotoxic agent

MedKoo Cat#: 464211 | Name: HCT-13

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HCT-13 is a novel copper-dependent cytotoxic agent, being highly potent against a panel of pancreatic, small cell lung carcinoma, prostate cancer, and leukemia models, with IC50 values in the low-to-mid nanomolar range.

Chemical Structure

HCT-13

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464211

Name: HCT-13

CAS#: unknown

Chemical Formula: C13H13FN4S

Exact Mass: 276.0845

Molecular Weight: 276.33

Elemental Analysis: C, 56.51; H, 4.74; F, 6.88; N, 20.28; S, 11.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HCT-13; HCT13; HCT 13;

IUPAC/Chemical Name

(E)-2-((6-fluoroisoquinolin-1-yl)methylene)-N,N-dimethylhydrazine-1-carbothioamide

InChi Key

DMHFSJTVHZZSAN-LZYBPNLTSA-N

InChi Code

InChI=1S/C13H13FN4S/c1-18(2)13(19)17-16-8-12-11-4-3-10(14)7-9(11)5-6-15-12/h3-8H,1-2H3,(H,17,19)/b16-8+

SMILES Code

S=C(N/N=C/C1=NC=CC2=C1C=CC(F)=C2)N(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

to be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	To be determined	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 276.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sun DL, Poddar S, Pan RD, Rosser EW, Abt ER, Van Valkenburgh J, Le TM, Lok V, Hernandez SP, Song J, Li J, Turlik A, Chen X, Cheng CA, Chen W, Mona CE, Stuparu AD, Vergnes L, Reue K, Damoiseaux R, Zink JI, Czernin J, Donahue TR, Houk KN, Jung ME, Radu CG. Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias. RSC Med Chem. 2020 Feb 24;11(3):392-410. doi: 10.1039/c9md00594c. PMID: 33479645; PMCID: PMC7593890.