Sulfadiazine-d4 | CAS#1020719-78-1 | Sulfadiazine quantification internal standard

MedKoo Cat#: 464192 | Name: Sulfadiazine-d4

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulfadiazine-d4 is intended for use as an internal standard for the quantification of sulfadiazine by GC- or LC-MS. Sulfadiazine is a sulfonamide antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria. It inhibits dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA) to dihydropteroate, an intermediate in folate biosynthesis. Sulfadiazine inhibits recombinant P. carinii DHPS (IC50 = 0.19 μM). It is active against clinical isolates of M. tuberculosis (MIC90 = 10 mg/L) and of N. meningitidis (MICs = 5-2,000 mg/L). Sulfadiazine is also active against A. pleuropneumoniae, S. choleraesuis, S. typhimurium, P. multocida, S. equi, and S. suis (MIC90s = <0.5 mg/ml for all) when used in combination with trimethoprim. In vivo, sulfadiazine (40 mg/kg per day) increases survival in a mouse model of lethal T. gondii infection when administered in combination with pyrimethamine. Formulations containing sulfadiazine have been used in the treatment of rheumatic fever and various infections, and, in a dual treatment with pyrimethamine, to treat toxoplasmosis.

Chemical Structure

Sulfadiazine-d4

CAS#1020719-78-1

Theoretical Analysis

MedKoo Cat#: 464192

Name: Sulfadiazine-d4

CAS#: 1020719-78-1

Chemical Formula: C10H6D4N4O2S

Exact Mass: 254.0776

Molecular Weight: 254.30

Elemental Analysis: C, 47.23; H, 5.55; N, 22.03; O, 12.58; S, 12.61

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 600.00	2 Weeks
5mg	USD 1,625.00	2 Weeks

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Synonym

Sulfadiazine-d4; Sulfadiazine d4;

IUPAC/Chemical Name

4-amino-N-(pyrimidin-2-yl)benzene-2,3,5,6-d4-sulfonamide

InChi Key

SEEPANYCNGTZFQ-QFFDRWTDSA-N

InChi Code

InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)/i2D,3D,4D,5D

SMILES Code

O=S(NC1=NC=CC=N1)(C2=C(C([2H])=C(N)C([2H])=C2[2H])[2H])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

to be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	To be determined	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 254.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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