MedKoo Cat#: 464190 | Name: Cysteamine-d4 HCl
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cysteamine-d4 is intended for use as an internal standard for the quantification of cysteamine (hydrochloride) by GC- or LC-MS. Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.

Chemical Structure

Cysteamine-d4 HCl
Cysteamine-d4 HCl
CAS#1219805-04-5

Theoretical Analysis

MedKoo Cat#: 464190

Name: Cysteamine-d4 HCl

CAS#: 1219805-04-5

Chemical Formula: C2H4D4ClNS

Exact Mass: 117.0317

Molecular Weight: 117.63

Elemental Analysis: C, 20.42; H, 10.28; Cl, 30.14; N, 11.91; S, 27.26

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Cysteamine-d4 HCl; Cysteamine d4 HCl; Cysteamine d4 hydrochloride; Cysteamine-d4 hydrochloride; β-Mercaptoethylamine-d4; β Mercaptoethylamine d4;
IUPAC/Chemical Name
2-aminoethane-1,1,2,2-d4-1-thiol hydrochloride
InChi Key
OGMADIBCHLQMIP-PBCJVBLFSA-N
InChi Code
InChI=1S/C2H7NS.ClH/c3-1-2-4;/h4H,1-3H2;1H/i1D2,2D2;
SMILES Code
NC([2H])(C([2H])(S)[2H])[2H].Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 117.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Quan W, Jiao Y, Li Y, Xue C, Liu G, Wang Z, Qin F, He Z, Zeng M, Chen J. Metabolic changes from exposure to harmful Maillard reaction products and high- fat diet on Sprague-Dawley rats. Food Res Int. 2021 Mar;141:110129. doi: 10.1016/j.foodres.2021.110129. Epub 2021 Jan 9. PMID: 33641996. 2: Rani D, Nayak B, Srivastava S. Immunogenicity of gold nanoparticle-based truncated ORF2 vaccine in mice against Hepatitis E virus. 3 Biotech. 2021 Feb;11(2):49. doi: 10.1007/s13205-020-02573-y. Epub 2021 Jan 11. PMID: 33457173; PMCID: PMC7799426. 3: Iyob-Tessema H, Wang CS, Kennedy S, Reyes L, Shin S, Greenbaum LA, Hogan J. Grip Strength in Adults and Children with Cystinosis. Kidney Int Rep. 2020 Nov 24;6(2):389-395. doi: 10.1016/j.ekir.2020.11.017. PMID: 33615064; PMCID: PMC7879123. 4: Oldak L, Sankiewicz A, Żelazowska-Rutkowska B, Cylwik B, Lukaszewski Z, Skoczylas M, Gorodkiewicz E. Two SPRi biosensors for the determination of cathepsin S in blood plasma. Talanta. 2021 Apr 1;225:121900. doi: 10.1016/j.talanta.2020.121900. Epub 2020 Dec 4. PMID: 33592693. 5: Jimenez J, Washington MA, Resnick JL, Nischal KK, Fedorchak MV. A sustained release cysteamine microsphere/thermoresponsive gel eyedrop for corneal cystinosis improves drug stability. Drug Deliv Transl Res. 2021 Feb 4. doi: 10.1007/s13346-020-00890-6. Epub ahead of print. PMID: 33543397. 6: Crinelli R, Zara C, Galluzzi L, Buffi G, Ceccarini C, Smietana M, Mari M, Magnani M, Fraternale A. Activation of NRF2 and ATF4 Signaling by the Pro- Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. Antioxidants (Basel). 2021 Jan 26;10(2):175. doi: 10.3390/antiox10020175. PMID: 33530504; PMCID: PMC7911873. 7: Khanna K, Raymond W, Charbit AR, Jin J, Gitlin I, Tang M, Sperber HS, Franz S, Pillai S, Simmons G, Fahy JV. Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies. bioRxiv [Preprint]. 2020 Dec 8:2020.12.08.415505. doi: 10.1101/2020.12.08.415505. PMID: 33330868; PMCID: PMC7743076. 8: Niedziałkowski P, Bojko M, Ryl J, Wcisło A, Spodzieja M, Magiera-Mularz K, Guzik K, Dubin G, Holak TA, Ossowski T, Rodziewicz-Motowidło S. Ultrasensitive electrochemical determination of the cancer biomarker protein sPD-L1 based on a BMS-8-modified gold electrode. Bioelectrochemistry. 2021 Jun;139:107742. doi: 10.1016/j.bioelechem.2021.107742. Epub 2021 Jan 18. PMID: 33517203. 9: Zhang Z, Zhou C, Fan K, Zhang L, Liu Y, Liu PF. Metabolomics analysis of the effects of temperature on the growth and development of juvenile European seabass (Dicentrarchus labrax). Sci Total Environ. 2021 Jan 14;769:145155. doi: 10.1016/j.scitotenv.2021.145155. Epub ahead of print. PMID: 33485208. 10: Shen D, Tian L, Yang F, Li J, Li X, Yao Y, Lam EW, Gao P, Jin B, Wang R. ADO/hypotaurine: a novel metabolic pathway contributing to glioblastoma development. Cell Death Discov. 2021 Jan 22;7(1):21. doi: 10.1038/s41420-020-00398-5. PMID: 33483477; PMCID: PMC7822925. 11: Kalyani T, Nanda A, Jana SK. Detection of a novel glycodelin biomarker using electrochemical immunosensor for endometriosis. Anal Chim Acta. 2021 Feb 15;1146:146-154. doi: 10.1016/j.aca.2020.11.015. Epub 2020 Nov 18. PMID: 33461710. 12: Atallah C, Charcosset C, Greige-Gerges H. Challenges for cysteamine stabilization, quantification, and biological effects improvement. J Pharm Anal. 2020 Dec;10(6):499-516. doi: 10.1016/j.jpha.2020.03.007. Epub 2020 Mar 21. PMID: 33425447; PMCID: PMC7775854. 13: Sankiewicz A , Hermanowicz A , Grycz A , Łukaszewski Z , Gorodkiewicz E . An SPR imaging immunosensor for leptin determination in blood plasma. Anal Methods. 2021 Feb 7;13(5):642-646. doi: 10.1039/d0ay02047h. Epub 2021 Jan 13. PMID: 33438698. 14: Novák D, Vrba J, Zatloukalová M, Roubalová L, Stolarczyk K, Dorčák V, Vacek J. Cysteamine assay for the evaluation of bioactive electrophiles. Free Radic Biol Med. 2021 Feb 20;164:381-389. doi: 10.1016/j.freeradbiomed.2021.01.007. Epub 2021 Jan 9. PMID: 33429019. 15: Liu K, Zhang J, Jiang J, Xu T, Wang S, Chang P, Zhang Z, Ma J, Liu T. Multi- layer optical fiber surface plasmon resonance biosensor based on a sandwich structure of polydopamine-MoSe2@Au nanoparticles-polydopamine. Biomed Opt Express. 2020 Nov 3;11(12):6840-6851. doi: 10.1364/BOE.409535. PMID: 33408965; PMCID: PMC7747900. 16: Ozcan HM, Aydin UD. A simple immunosensor for thyroid stimulating hormone. Artif Cells Nanomed Biotechnol. 2021 Dec;49(1):61-70. doi: 10.1080/21691401.2020.1867153. PMID: 33410369. 17: Zhang J, Yang W, Li S, Bian L. Fluorescent reversible regulation of cysteamine-capped ZnSe quantum dots successively induced by photoinduced electron transfer of herring sperm DNA and intercalation binding of ethidium bromide. Spectrochim Acta A Mol Biomol Spectrosc. 2021 Mar 15;249:119116. doi: 10.1016/j.saa.2020.119116. Epub 2020 Oct 27. PMID: 33385973. 18: Devereux G, Wrolstad D, Bourke SJ, Daines CL, Doe S, Dougherty R, Franco R, Innes A, Kopp BT, Lascano J, Layish D, MacGregor G, Murray L, Peckham D, Lucidi V, Lovie E, Robertson J, Fraser-Pitt DJ, O'Neil DA. Oral cysteamine as an adjunct treatment in cystic fibrosis pulmonary exacerbations: An exploratory randomized clinical trial. PLoS One. 2020 Dec 28;15(12):e0242945. doi: 10.1371/journal.pone.0242945. PMID: 33370348; PMCID: PMC7769283. 19: De Palma FDE, Raia V, Kroemer G, Maiuri MC. The Multifaceted Roles of MicroRNAs in Cystic Fibrosis. Diagnostics (Basel). 2020 Dec 17;10(12):1102. doi: 10.3390/diagnostics10121102. PMID: 33348555; PMCID: PMC7765910. 20: Lee CM. A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women: the devil is in the detail. Int J Dermatol. 2021 Feb;60(2):255. doi: 10.1111/ijd.15373. Epub 2020 Dec 17. PMID: 33332600.