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MedKoo Cat#: 464165 | Name: Aldosterone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aldosterone is a mineralocorticoid hormone produced by aldosterone synthase (CYP11B2) in the zona glomerulosa of the adrenal cortex.

Chemical Structure

Aldosterone
Aldosterone
CAS#52-39-1

Theoretical Analysis

MedKoo Cat#: 464165

Name: Aldosterone

CAS#: 52-39-1

Chemical Formula: C21H28O5

Exact Mass: 360.1937

Molecular Weight: 360.45

Elemental Analysis: C, 69.98; H, 7.83; O, 22.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Aldosterone;
IUPAC/Chemical Name
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,3,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-13H-cyclopenta[a]phenanthrene-13-carbaldehyde
InChi Key
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
InChi Code
InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
SMILES Code
O=C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 360.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hanff TC, Cohen JB, Zhao L, Javaheri A, Zamani P, Prenner SB, Rietzschel E, Jia Y, Walsh A, Maranville J, Wang Z, Adam L, Ramirez-Valle F, Schafer P, Seiffert D, Gordon DA, Cvijic ME, Cappola TP, Chirinos JA. Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction. JACC Basic Transl Sci. 2021 Feb 10;6(2):89-99. doi: 10.1016/j.jacbts.2020.11.011. PMID: 33665511; PMCID: PMC7907637. 2: Beldhuis IE, Myhre PL, Bristow M, Claggett B, Damman K, Fang JC, Fleg JL, McKinlay S, Lewis EF, O'Meara E, Pitt B, Shah SJ, Vardeny O, Voors AA, Pfeffer MA, Solomon SD, Desai AS. Spironolactone in Patients With Heart Failure, Preserved Ejection Fraction, and Worsening Renal Function. J Am Coll Cardiol. 2021 Mar 9;77(9):1211-1221. doi: 10.1016/j.jacc.2020.12.057. PMID: 33663739. 3: Ramirez-Jimenez M, Morales-Palomo F, Moreno-Cabañas A, Alvarez-Jimenez L, Ortega JF, Mora-Rodriguez R. Effects of antihypertensive medication and high- intensity interval training in hypertensive metabolic syndrome individuals. Scand J Med Sci Sports. 2021 Mar 4. doi: 10.1111/sms.13949. Epub ahead of print. PMID: 33662166. 4: Perkins BA, Lovblom LE, Lanctôt SO, Lamb K, Cherney DZI. Discoveries from the study of longstanding type 1 diabetes. Diabetologia. 2021 Mar 4. doi: 10.1007/s00125-021-05403-9. Epub ahead of print. PMID: 33661335. 5: Khoury EE, Knaney Y, Fokra A, Kinaneh S, Azzam Z, Heyman SN, Abassi Z. Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease. J Cell Mol Med. 2021 Mar 4. doi: 10.1111/jcmm.16310. Epub ahead of print. PMID: 33660945. 6: Hundemer GL, Kline GA, Leung AA. How common is primary aldosteronism? Curr Opin Nephrol Hypertens. 2021 Mar 1. doi: 10.1097/MNH.0000000000000702. Epub ahead of print. PMID: 33660617. 7: Caroccia B, Vanderriele PE, Seccia TM, Piazza M, Lenzini L, Prisco S, Torresan F, Domening O, Iacobone M, Poglitsch M, Rossi GP. Aldosterone and cortisol synthesis regulation by angiotensin-(1-7) and angiotensin-converting enzyme 2 in the human adrenal cortex. J Hypertens. 2021 Mar 1. doi: 10.1097/HJH.0000000000002816. Epub ahead of print. PMID: 33657582. 8: Takeda Y, Demura M, Wang F, Karashima S, Yoneda T, Kometani M, Aomo D, Hashimoto A, Horike SI, Meguro-Horike M, Takeda Y. Effect of potassium on DNA methylation of aldosterone synthase gene. J Hypertens. 2021 Mar 3. doi: 10.1097/HJH.0000000000002742. Epub ahead of print. PMID: 33657579. 9: Cice G, Monzo L, Calo L. The uraemic hypertensive patient: a therapeutic challenge-right you are (if you think so). Eur Heart J Suppl. 2020 Nov 18;22(Suppl L):L44-L48. doi: 10.1093/eurheartj/suaa133. PMID: 33654466; PMCID: PMC7904065. 10: Katsu Y, Shariful IMD, Lin X, Takagi W, Urushitani H, Kohno S, Hyodo S, Baker ME. N-terminal Domain Regulates Steroid Activation of Elephant Shark Glucocorticoid and Mineralocorticoid Receptors. J Steroid Biochem Mol Biol. 2021 Feb 27:105845. doi: 10.1016/j.jsbmb.2021.105845. Epub ahead of print. PMID: 33652098. 11: Zhang Q, Pan Y, Ma X, Yang H, Chang J, Hong L, Yan H, Zhang SH. Elevated Secretion of Aldosterone Increases TG/HDL-C Ratio and Potentiates The Ox-LDL- Induced Dysfunction of HUVEC. Cell J. 2021 Apr;23(1):61-69. doi: 10.22074/cellj.2021.7033. Epub 2021 Mar 1. PMID: 33650821. 12: Essigke D, Ilyaskin AV, Wörn M, Bohnert BN, Xiao M, Daniel C, Amann K, Birkenfeld AL, Szabo R, Bugge TH, Korbmacher C, Artunc F. Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice. Acta Physiol (Oxf). 2021 Mar 1:e13640. doi: 10.1111/apha.13640. Epub ahead of print. PMID: 33650216. 13: Santos A, Magro DO, Evangelista-Poderoso R, Saad MJA. Diabetes, obesity, and insulin resistance in COVID-19: molecular interrelationship and therapeutic implications. Diabetol Metab Syndr. 2021 Mar 1;13(1):23. doi: 10.1186/s13098-021-00639-2. PMID: 33648564; PMCID: PMC7919999. 14: Zhou X, Cui H, Zhang Q, Hayat K, Yu J, Hussain S, Tahir MU, Zhang X, Ho CT. Taste improvement of Maillard reaction intermediates derived from enzymatic hydrolysates of pea protein. Food Res Int. 2021 Feb;140:109985. doi: 10.1016/j.foodres.2020.109985. Epub 2020 Dec 16. PMID: 33648220. 15: Nishiwaki H, Niihata K, Shimizu S, Shibagaki Y, Yamamoto R, Nitta K, Tsukamoto T, Uchida S, Takeda A, Okada H, Narita I, Isaka Y, Kurita N; Japan Nephrotic Syndrome Cohort Study group. Incidence and factors associated with prescribing renin-angiotensin-system inhibitors in adult idiopathic nephrotic syndrome: A nationwide cohort study. J Clin Hypertens (Greenwich). 2021 Mar 1. doi: 10.1111/jch.14224. Epub ahead of print. PMID: 33645883. 16: Teragawa H, Oshita C, Orita Y, Hashimoto K, Nakayama H, Yamazaki Y, Sasano H. Primary aldosteronism due to bilateral micronodular hyperplasia and concomitant subclinical Cushing's syndrome: A case report. World J Clin Cases. 2021 Feb 16;9(5):1119-1126. doi: 10.12998/wjcc.v9.i5.1119. PMID: 33644175; PMCID: PMC7896658. 17: Pironti G, Andersson DC, Lund LH. Mechanistic and Therapeutic Implications of Extracellular Vesicles as a Potential Link Between Covid-19 and Cardiovascular Disease Manifestations. Front Cell Dev Biol. 2021 Feb 11;9:640723. doi: 10.3389/fcell.2021.640723. PMID: 33644077; PMCID: PMC7905102. 18: Nakano Y, Iwata N, Ogura-Ochi K, Hasegawa K, Hirasawa A, Otsuka F. Preclinical diagnosis and identification of the chimeric CYP11B1/CYP11B2 gene in two pediatric cases of a Japanese family with glucocorticoid-remediable aldosteronism. Hypertens Res. 2021 Mar 1. doi: 10.1038/s41440-021-00633-1. Epub ahead of print. PMID: 33642567. 19: Kario K, Hettrick DA, Prejbisz A, Januszewicz A. Obstructive Sleep Apnea- Induced Neurogenic Nocturnal Hypertension: A Potential Role of Renal Denervation? Hypertension. 2021 Mar 1:HYPERTENSIONAHA12016378. doi: 10.1161/HYPERTENSIONAHA.120.16378. Epub ahead of print. PMID: 33641363. 20: Adolf C, Görge V, Heinrich DA, Hoster E, Schneider H, Handgriff L, Künzel H, Sturm L, Beuschlein F, Reincke M. Altered Taste Perception for Sodium Chloride in Patients With Primary Aldosteronism: A Prospective Cohort Study. Hypertension. 2021 Mar 1:HYPERTENSIONAHA12016440. doi: 10.1161/HYPERTENSIONAHA.120.16440. Epub ahead of print. PMID: 33641355.