PT3 | CAS#2710273-81-5 | HDA3 Inhibitor

MedKoo Cat#: 464163 | Name: PT3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PT3 is a novel Benzamide Class Histone Deacetylase 3 (HDAC3) Inhibitor. PT3 showed activity to Improve Learning and Memory in Novel Object Recognition Mouse Model. PT3 has an excellent blood-brain barrier permeability and ability to enhance long-term memory in mouse model of novel object recognition (NOR). PT3 exhibited higher selectivity for HDAC3 over HDAC1, HDAC6, and HDAC8 compared to the reference compound CI994. PT3 has significant distribution into the brain tissue with Cmax at 0.5 h and t1/2 of 2.5 h. Treatment with PT3 significantly improved the discrimination index in C57/BL6 mice in the NOR model. Brain tissue analysis of mice treated with PT3 for NOR test showed significant increase in H3K9 acetylation in hippocampus.

Chemical Structure

PT3

CAS#2710273-81-5

Theoretical Analysis

MedKoo Cat#: 464163

Name: PT3

CAS#: 2710273-81-5

Chemical Formula: C18H17N5O

Exact Mass: 319.1433

Molecular Weight: 319.37

Elemental Analysis: C, 67.70; H, 5.37; N, 21.93; O, 5.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

PT3; PT 3; PT-3;

IUPAC/Chemical Name

N-(2-aminophenyl)-5-(benzylamino)pyrazine-2-carboxamide

InChi Key

VNDKSSOLKIUTSX-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H17N5O/c19-14-8-4-5-9-15(14)23-18(24)16-11-22-17(12-20-16)21-10-13-6-2-1-3-7-13/h1-9,11-12H,10,19H2,(H,21,22)(H,23,24)

SMILES Code

O=C(C1=NC=C(NCC2=CC=CC=C2)N=C1)NC3=CC=CC=C3N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

The importance of HDAC3 in transcriptional regulation of genes associated with long-term memory is well established. Gene expression analysis by RT-qPCR of the hippocampus tissue revealed upregulation of CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43, PSD 95 and MMP9 expression in mice treated with PT3. Similar to the phenotype observed in the in vivo experiment, we found upregulation of H3K9 acetylation, CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43 and MMP9 expression in mouse neuronal (N2A) cells treated with PT3. Thus, our preclinical studies identify PT3 as a potential HDAC3 selective inhibitor that crosses the blood-brain barrier and improves the long-term memory formation in C57/BL6 mice. We propose PT3 as a candidate with therapeutic potential to treat age-related memory loss as well as other disorders with declined memory function like Alzheimer's disease.

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 319.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.