Theodrenaline | CAS# 13460-98-5 | cardiac stimulant

MedKoo Cat#: 413443 | Name: Theodrenaline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Theodrenaline is a chemical linkage of norepinephrine and theophylline used as a cardiac stimulant. It is sometimes combined with cafedrine.

Chemical Structure

Theodrenaline

CAS#13460-98-5

Theoretical Analysis

MedKoo Cat#: 413443

Name: Theodrenaline

CAS#: 13460-98-5

Chemical Formula: C17H21N5O5

Exact Mass: 375.1543

Molecular Weight: 375.39

Elemental Analysis: C, 54.39; H, 5.64; N, 18.66; O, 21.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Theodrenaline; D470; D-470; D 470

IUPAC/Chemical Name

7-(2-((2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)amino)ethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

InChi Key

WMCMJIGLYZDKRN-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H21N5O5/c1-20-15-14(16(26)21(2)17(20)27)22(9-19-15)6-5-18-8-13(25)10-3-4-11(23)12(24)7-10/h3-4,7,9,13,18,23-25H,5-6,8H2,1-2H3

SMILES Code

CN1C(N(c2c(C1=O)n(CCNCC(c3cc(O)c(O)cc3)O)cn2)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM	comments
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 375.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bein B, Christ T, Eberhart LH. Cafedrine/Theodrenaline (20:1) Is an Established Alternative for the Management of Arterial Hypotension in Germany-a Review Based on a Systematic Literature Search. Front Pharmacol. 2017 Feb 21;8:68. doi: 10.3389/fphar.2017.00068. PMID: 28270765; PMCID: PMC5318387. 2: Weitzel M, Hammels P, Schorer C, Klingler H, Weyland A. Hämodynamisches Wirkungsspektrum von Cafedrin/Theodrenalin bei Anästhesie-assoziierter Hypotension [Hemodynamic effects of cafedrine/theodrenaline on anesthesia- induced hypotension]. Anaesthesist. 2018 Oct;67(10):766-772. German. doi: 10.1007/s00101-018-0472-z. Epub 2018 Aug 21. PMID: 30132111. 3: Heller AR, Heger J, Gama de Abreu M, Müller MP. Cafedrine/theodrenaline in anaesthesia: influencing factors in restoring arterial blood pressure. Anaesthesist. 2015 Mar;64(3):190-6. doi: 10.1007/s00101-015-0005-y. Epub 2015 Mar 11. PMID: 25757552; PMCID: PMC4383809. 4: Eberhart L, Geldner G, Kowark A, Zucker TP, Kreuer S, Przemeck M, Huljic S, Koch T, Keller T, Weber S, Kranke P; HYPOTENS study group. Treatment of intraoperative hypotension with cafedrine/theodrenaline versus ephedrine : A prospective, national, multicenter, non-interventional study-the HYPOTENS trial. Anaesthesist. 2020 Nov 10. English. doi: 10.1007/s00101-020-00877-5. Epub ahead of print. Erratum in: Anaesthesist. 2021 Feb 26;: PMID: 33170310. 5: Kloth B, Pecha S, Moritz E, Schneeberger Y, Söhren KD, Schwedhelm E, Reichenspurner H, Eschenhagen T, Böger RH, Christ T, Stehr SN. AkrinorTM, a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro. Front Pharmacol. 2017 May 23;8:272. doi: 10.3389/fphar.2017.00272. PMID: 28588484; PMCID: PMC5441130. 6: Chappell D, Helf A, Gayer J, Eberhart L, Kranke P. Antihypotensiva bei Kaiserschnittentbindungen : Behandlung der arteriellen Hypotension mit Ephedrin, Phenylephrin und Akrinor® (Cafedrin/Theodrenalin) im Rahmen von Kaiserschnittentbindungen in Spinalanästhesie [Antihypotensive drugs in cesarean sections : Treatment of arterial hypotension with ephedrine, phenylephrine and Akrinor® (cafedrine/theodrenaline) during cesarean sections with spinal anesthesia]. Anaesthesist. 2019 Apr;68(4):228-238. German. doi: 10.1007/s00101-019-0560-8. Epub 2019 Mar 27. PMID: 30918986. 7: Eberhart L, Geldner G, Huljic S, Marggraf K, Keller T, Koch T, Kranke P. A non-interventional comparative study of the 20:1 combination of cafedrine/theodrenaline versus ephedrine for the treatment of intra-operative arterial hypotension: the 'HYPOTENS' study design and rationale. Curr Med Res Opin. 2018 Jun;34(6):953-961. doi: 10.1080/03007995.2018.1438379. Epub 2018 Feb 28. PMID: 29415580. 8: Strümper D, Gogarten W, Durieux ME, Hartleb K, Van Aken H, Marcus MA. Effects of cafedrine/theodrenaline, etilefrine and ephedrine on uterine blood flow during epidural-induced hypotension in pregnant sheep. Fetal Diagn Ther. 2005 Sep-Oct;20(5):377-82. doi: 10.1159/000086816. PMID: 16113557. 9: Clemens KE, Quednau I, Heller AR, Klaschik E. Impact of cafedrine/theodrenaline (Akrinor® ) on therapy of maternal hypotension during spinal anesthesia for Cesarean delivery: a retrospective study. Minerva Ginecol. 2010 Dec;62(6):515-24. PMID: 21079573. 10: Raimann FJ, Baldauf HP, Louwen F, Jennewein L, Fischer D, Zacharowski K, Weber CF. Granisetron reduces the need for uterotonics but not sympathomimetics during cesarean delivery. Int J Gynaecol Obstet. 2019 Jun;145(3):361-366. doi: 10.1002/ijgo.12819. Epub 2019 Apr 15. PMID: 30932170.