Cytogenin | CAS# 132971-59-6 | antitumor agent

MedKoo Cat#: 413435 | Name: Cytogenin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cytogenin is a microbial product that was found to be an orally active antitumor agent against murine tumors.

Chemical Structure

Cytogenin

CAS#132971-59-6

Theoretical Analysis

MedKoo Cat#: 413435

Name: Cytogenin

CAS#: 132971-59-6

Chemical Formula: C11H10O5

Exact Mass: 222.0528

Molecular Weight: 222.19

Elemental Analysis: C, 59.46; H, 4.54; O, 36.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Cytogenin; Antibiotic MI 43-37F 11;

IUPAC/Chemical Name

8-Hydroxy-3-(hydroxymethyl)-6-methoxy-1H-2-benzopyran-1-one

InChi Key

CAWNOJXNAUEIGB-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H10O5/c1-15-7-2-6-3-8(5-12)16-11(14)10(6)9(13)4-7/h2-4,12-13H,5H2,1H3

SMILES Code

O=C1C2=C(O)C=C(OC)C=C2C=C(CO)O1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 222.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hirano S, Wakazono K, Agata N, Mase T, Yamamoto R, Matsufuji M, Sakata N, Iguchi H, Tone H, Ishizuka M, et al. Effects of cytogenin, a novel anti- arthritic agent, on type II collagen-induced arthritis in DBA/1J mice and adjuvant arthritis in Lewis rats. Int J Tissue React. 1994;16(4):155-62. PMID: 7797401. 2: Kumagai H, Amemiya M, Naganawa H, Sawa T, Ishizuka M, Takeuchi T. Biosynthesis of antitumor antibiotic, cytogenin. J Antibiot (Tokyo). 1994 Apr;47(4):440-6. doi: 10.7164/antibiotics.47.440. PMID: 8195044. 3: Kumagai H, Wakazono K, Agata N, Isshiki K, Ishizuka M, Ikeda D. Effect of cytogenin, a novel immunomodulator, on streptozotocin-induced diabetes in mice. J Antibiot (Tokyo). 2005 Mar;58(3):202-5. doi: 10.1038/ja.2005.24. PMID: 15895529. 4: Oikawa T, Sasaki M, Inose M, Shimamura M, Kuboki H, Hirano S, Kumagai H, Ishizuka M, Takeuchi T. Effects of cytogenin, a novel microbial product, on embryonic and tumor cell-induced angiogenic responses in vivo. Anticancer Res. 1997 May-Jun;17(3C):1881-6. PMID: 9216639. 5: Kumagai H, Masuda T, Ohsono M, Hattori S, Naganawa H, Sawa T, Hamada M, Ishizuka M, Takeuchi T. Cytogenin, a novel antitumor substance. J Antibiot (Tokyo). 1990 Nov;43(11):1505-7. doi: 10.7164/antibiotics.43.1505. PMID: 2272926. 6: Kumagai H, Osono M, Iijima M, Sakashita M, Ishizuka M, Takeuchi T. Action of cytogenin on lymphoid cells and their cytokine production. J Antibiot (Tokyo). 1995 Apr;48(4):317-20. doi: 10.7164/antibiotics.48.317. PMID: 7775269. 7: Kumagai H, Masuda T, Ishizuka M, Takeuchi T. Antitumor activity of cytogenin. J Antibiot (Tokyo). 1995 Feb;48(2):175-8. doi: 10.7164/antibiotics.48.175. PMID: 7706130. 8: Abe C, Hirano S, Wakazono K, Mase T, Yamamoto R, Matsufuji M, Sakata N, Agata N, Iguchi H, Ishizuka M, et al. Effects of cytogenin on spontaneous arthritis in MRL/1 mice and on pristane-induced arthritis (PIA) in DBA/1J mice. Int J Tissue React. 1995;17(5-6):175-80. PMID: 8835627. 9: Kumagai H, Masuda T, Sakashita M, Ishizuka M, Takeuchi T. Modulation of macrophage activity in tumor bearing mice by cytogenin. J Antibiot (Tokyo). 1995 Apr;48(4):321-5. doi: 10.7164/antibiotics.48.321. PMID: 7775270. 10: Matsumoto N, Nakashima T, Isshiki K, Kuboki H, Hirano SI, Kumagai H, Yoshioka T, Ishizuka M, Takeuchi T. Synthesis and biological evaluation of cytogenin derivatives. J Antibiot (Tokyo). 2001 Mar;54(3):285-96. doi: 10.7164/antibiotics.54.285. PMID: 11372785.