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MedKoo Cat#: 464125 | Name: THS-975

Description:

WARNING: This product is for research use only, not for human or veterinary use.

THS-975 is a Potent and Selective Cytosolic Hsp90 Inhibitor.

Chemical Structure

THS-975
THS-975
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464125

Name: THS-975

CAS#: unknown

Chemical Formula: C16H17N7

Exact Mass: 307.1545

Molecular Weight: 307.36

Elemental Analysis: C, 62.52; H, 5.58; N, 31.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
THS-975; THS975; THS 975;
IUPAC/Chemical Name
3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine
InChi Key
LSEUNLIDRFFKFN-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H17N7/c1-10(2)15-14-13(4-5-17-16(14)21-20-15)23-8-12(18-9-23)11-6-19-22(3)7-11/h4-10H,1-3H3,(H,17,20,21)
SMILES Code
CN1N=CC(C2=CN(C=N2)C3=C4C(NN=C4C(C)C)=NC=C3)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 307.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yoshimura C, Nagatoishi S, Kuroda D, Kodama Y, Uno T, Kitade M, Chong-Takata K, Oshiumi H, Muraoka H, Yamashita S, Kawai Y, Ohkubo S, Tsumoto K. Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors. J Med Chem. 2021 Feb 23. doi: 10.1021/acs.jmedchem.0c01715. Epub ahead of print. PMID: 33621080.