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MedKoo Cat#: 413412 | Name: Artemisiifolin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Artemisiifolin and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for her discovery. Treatments containing an artemisinin derivative

Chemical Structure

Artemisiifolin
CAS#26931-87-3

Theoretical Analysis

MedKoo Cat#: 413412

Name: Artemisiifolin

CAS#: 26931-87-3

Chemical Formula: C15H20O4

Exact Mass: 264.1362

Molecular Weight: 264.32

Elemental Analysis: C, 68.16; H, 7.63; O, 24.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Artemisiifolin; NSC177852; NSC 177852; NSC-177852
IUPAC/Chemical Name
Cyclodeca(b)furan-2(3H)-one, 3a,4,7,8,11,11a-hexahydro-4-hydroxy-6-(hydroxymethyl)-10-methyl-3-methylene-, (3aS,4R,5Z,9E,11aS)-
InChi Key
WMFCEEAYDCXJCA-MRPJSKIDSA-N
InChi Code
InChI=1S/C15H20O4/c1-9-4-3-5-11(8-16)7-12(17)14-10(2)15(18)19-13(14)6-9/h4,7,12-14,16-17H,2-3,5-6,8H2,1H3/b9-4+,11-7-/t12-,13+,14+/m1/s1
SMILES Code
O=C(O[C@]1([H])[C@]2([H])[C@H](O)/C=C(CO)/CC/C=C(C)/C1)C2=C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 264.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang Y, Dong Z, Zhao D, Li H, Wang L, Lin Y, Zhao P. [Comparison of chemical constituents of wild silkworm cocoon and domestic silkworm cocoon by UHPLC-MS technology]. Sheng Wu Gong Cheng Xue Bao. 2019 Aug 25;35(8):1546-1556. Chinese. doi: 10.13345/j.cjb.190027. PMID: 31441626. 2: Álvarez-Calero JM, Ruiz E, López-Pérez JL, Jaraíz M, Rubio JE, Jorge ZD, Suárez M, Massanet GM. 15-Hydroxygermacranolides as Sources of Structural Diversity: Synthesis of Sesquiterpene Lactones by Cyclization and Rearrangement Reactions. Experimental and DFT Study. J Org Chem. 2018 May 18;83(10):5480-5495. doi: 10.1021/acs.joc.8b00407. Epub 2018 May 3. PMID: 29694044. 3: Jimeno ML, del Carmen Apreda-Rojas M, Cano FH, Rodríguez B. NMR and x-ray conformational study of artemisiifolin and three other related germacranolides. Magn Reson Chem. 2004 May;42(5):474-83. doi: 10.1002/mrc.1352. PMID: 15095384.