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MedKoo Cat#: 413408 | Name: Cyclizine tartrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyclizine tartrate is used as an antiemetic in the management of nausea and vomiting including motion sickness, postoperative nausea and vomiting,.

Chemical Structure

Cyclizine tartrate
Cyclizine tartrate
CAS#84057-82-9 (tartrate)

Theoretical Analysis

MedKoo Cat#: 413408

Name: Cyclizine tartrate

CAS#: 84057-82-9 (tartrate)

Chemical Formula: C22H28N2O6

Exact Mass: 416.1947

Molecular Weight: 416.47

Elemental Analysis: C, 63.45; H, 6.78; N, 6.73; O, 23.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
303-25-3 (HCl); 5897-18-7 (2HCl); 5897-19-8 (lactate); 303-25-3 (HCl); 82-92-8 (free base)
Synonym
Cyclizine tartrate; EINECS 281-899-9; UNII-NWO82JA8TB
IUPAC/Chemical Name
1-Benzhydryl-4-methylpiperazine (R-(R*,R*))-tartrate (1:1)
InChi Key
RZRUVHZEJGYXMW-LREBCSMRSA-N
InChi Code
InChI=1S/C18H22N2.C4H6O6/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;5-1(3(7)8)2(6)4(9)10/h2-11,18H,12-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
SMILES Code
CN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1.O[C@H]([C@H](C(O)=O)O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 416.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Borukhova S, Noël T, Hessel V. Continuous-Flow Multistep Synthesis of Cinnarizine, Cyclizine, and a Buclizine Derivative from Bulk Alcohols. ChemSusChem. 2015 Dec 9. doi: 10.1002/cssc.201501367. [Epub ahead of print] PubMed PMID: 26663906. 2: Arnestad M, Eldor KB, Stray-Pedersen A, Bachs L, Karinen R. Suicide due to cyclizine overdose. J Anal Toxicol. 2014 Mar;38(2):110-2. doi: 10.1093/jat/bkt100. Epub 2013 Dec 8. PubMed PMID: 24324230. 3: Ahmadi A, Khalili M, Chavrogh S, Nahri-Niknafs B. Synthesis and Anti-inflammatory Performance of Newly Cyclizine Derivatives on Adult Male Wistar Rats. Iran J Pharm Res. 2012 Fall;11(4):1027-37. PubMed PMID: 24250533; PubMed Central PMCID: PMC3813157. 4: Wojcikiewicz TG, Peck MJ. Transient paralysis after cyclizine administration. Anaesthesia. 2013 Dec;68(12):1284-5. doi: 10.1111/anae.12515. PubMed PMID: 24219270. 5: Norman B. Transient paralysis after cyclizine administration. Anaesthesia. 2013 Dec;68(12):1284. doi: 10.1111/anae.12512. PubMed PMID: 24219268. 6: Woodfield J, St George EJ. Post-operative cyclizine misuse. Scott Med J. 2013 Nov;58(4):e1-2. doi: 10.1177/0036933013508039. PubMed PMID: 24215049. 7: McDevitt L, Mowat IR. Transient paralysis after cyclizine administration. Anaesthesia. 2013 Oct;68(10):1084. doi: 10.1111/anae.12426. PubMed PMID: 24047307. 8: Kamour A, George S, Vale A. Prolonged tachycardia following analytically confirmed cyclizine ingestion. Clin Toxicol (Phila). 2013 Jun;51(5):456-7. doi: 10.3109/15563650.2013.794283. Epub 2013 May 7. PubMed PMID: 23646828. 9: Lee P. Locked-in syndrome as a result of cyclizine administration. J Pain Symptom Manage. 2013 May;45(5):e5-7. doi: 10.1016/j.jpainsymman.2013.02.005. Epub 2013 Apr 6. PubMed PMID: 23571205. 10: Al-Shaalan NH. Extractive spectrophotometric assay of cyclizine in a pharmaceutical formulation and biological fluids. Saudi Pharm J. 2012 Jul;20(3):255-62. doi: 10.1016/j.jsps.2012.02.002. Epub 2012 Feb 21. PubMed PMID: 24115904; PubMed Central PMCID: PMC3792629. ^