Carbamazepine-d10 | CAS#132183-78-9 | Carbamazepine quantification internal standard

MedKoo Cat#: 464111 | Name: Carbamazepine-d10

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carbamazepine-d10 is intended for use as an internal standard for the quantification of carbamazepine by GC- or LC-MS. Carbamazepine is an anticonvulsant. It reduces the occurrence of seizures in mouse models of tonic-clonic, or maximal electroshock-induced, seizures (ED50s = 15.46 and ~13 mg/kg, respectively). Dietary administration of carbamazepine (0.75% w/w) reduces immobility time in the tail suspension test. It also attenuates clonidine-induced aggressive behavior in mice. Formulations containing carbamazepine have been used in the treatment of epilepsy and bipolar disorder.

Chemical Structure

Carbamazepine-d10

CAS#132183-78-9

Theoretical Analysis

MedKoo Cat#: 464111

Name: Carbamazepine-d10

CAS#: 132183-78-9

Chemical Formula: C15H2D10N2O

Exact Mass: 246.1577

Molecular Weight: 246.34

Elemental Analysis: C, 73.14; H, 8.99; N, 11.37; O, 6.49

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 310.00	2 Weeks
5mg	USD 750.00	2 Weeks

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Related CAS #

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Synonym

Carbamazepine-d10; Carbamazepine d10; Carbazepine-d10; Carbazepine d10;

IUPAC/Chemical Name

5H-dibenzo[b,f]azepine-d10-5-carboxamide

InChi Key

FFGPTBGBLSHEPO-LHNTUAQVSA-N

InChi Code

InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)/i1D,2D,3D,4D,5D,6D,7D,8D,9D,10D

SMILES Code

O=C(N)N1C2=C(C([2H])=C(C([2H])=C2C([2H])=C(C3=C(C([2H])=C(C([2H])=C31)[2H])[2H])[2H])[2H])[2H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 246.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 33618992. 4: Wasim M, Mannan A, Ullah K, Yameen MA, Latif M, Ahmad T, Ullah M, Amirzada MI, Khan HU, Maheen S, Khan SA, Jamil QA, Bin Asad MHH, Hussain I. Effect of varying quantities of polymer on preparation and stability evaluation of carbamazepine cocrystals with dicarboxylic acid coformers. Pak J Pharm Sci. 2020 Jul;33(4(Supplementary)):1755-1761. PMID: 33612458. 5: Haseitel MA, Hardaman CG. Anticoncepción en mujeres epilépticas [Contraception in epileptic women]. Medicina (B Aires). 2021;81(1):62-68. Spanish. PMID: 33611246. 6: Bai Z, Jia K, Chen G, Liao X, Cao Z, Zhao Y, Zhang C, Lu H. Carbamazepine induces hepatotoxicity in zebrafish by inhibition of the Wnt/β-catenin signaling pathway. Environ Pollut. 2021 Feb 6;276:116688. doi: 10.1016/j.envpol.2021.116688. Epub ahead of print. PMID: 33611196. 7: García MA, Cristofoletti R, Abrahamsson B, Groot DW, Parr A, Polli JE, Mehta M, Shah VP, Tomakazu T, Dressman JB, Langguth P. 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Epub ahead of print. PMID: 33608873. 11: Gerstl L, Willimsky E, Rémi C, Noachtar S, Borggräfe I, Tacke M. A Systematic Review of Seizure-Freedom Rates in Patients With Benign Epilepsy of Childhood With Centrotemporal Spikes Receiving Antiepileptic Drugs. Clin Neuropharmacol. 2021 Feb 17. doi: 10.1097/WNF.0000000000000435. Epub ahead of print. PMID: 33605607. 12: Song Z, Chen J, Shen J, Jia Z, Wang Q, Jiang S, Xu X, Shi W. Endoscopy during neurotomy of the nervus intermedius for nervus intermedius neuralgia: a case report. Ann Transl Med. 2021 Jan;9(2):179. doi: 10.21037/atm-20-5951. PMID: 33569481; PMCID: PMC7867896. 13: Hou Z, Fang Q, Liu H, Li Y, Zhao Q, Zhang Z, Lei Y, Tian S. Photolytic kinetics of pharmaceutically active compounds from upper to lower estuarine waters: Roles of triplet-excited dissolved organic matter and halogen radicals. Environ Pollut. 2021 Feb 8;276:116692. doi: 10.1016/j.envpol.2021.116692. Epub ahead of print. 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