MedKoo Cat#: 555914 | Name: DKN14009
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DKN14009, also known as IL-1R antagonist, is a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88) that changes the interaction of MyD88 and IL-1 receptor type I (IL-1RI). This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

DKN14009
DKN14009
CAS#566914-00-9

Theoretical Analysis

MedKoo Cat#: 555914

Name: DKN14009

CAS#: 566914-00-9

Chemical Formula: C18H26N2O2

Exact Mass: 302.1994

Molecular Weight: 302.42

Elemental Analysis: C, 71.49; H, 8.67; N, 9.26; O, 10.58

Price and Availability

Size Price Availability Quantity
100mg USD 850.00 2 Weeks
200mg USD 1,450.00 2 Weeks
500mg USD 2,050.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,150.00 2 Weeks
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Related CAS #
No Data
Synonym
IL-1R Antagonist; TLR1; Hydrocinnamoyl-L-valyl Pyrrolidine; DKN14009; DKN 14009; DKN-14009;
IUPAC/Chemical Name
N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-benzenepropanamide
InChi Key
DAZSWUUAFHBCGE-KRWDZBQOSA-N
InChi Code
InChI=1S/C18H26N2O2/c1-14(2)17(18(22)20-12-6-7-13-20)19-16(21)11-10-15-8-4-3-5-9-15/h3-5,8-9,14,17H,6-7,10-13H2,1-2H3,(H,19,21)/t17-/m0/s1
SMILES Code
O=C(N[C@H](C(N1CCCC1)=O)C(C)C)CCC2=CC=CC=C2
Appearance
a solution in ethanol (100mg/mL)
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
TLR1 (DKN14009) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 302.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Bartfai T, Behrens MM, Gaidarova S, Pemberton J, Shivanyuk A, Rebek J Jr. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7971-6. doi: 10.1073/pnas.0932746100. Epub 2003 Jun 10. PMID: 12799462; PMCID: PMC164697.