Corticorelin acetate | CAS# 86784-80-7 | corticotropin-releasing factor

MedKoo Cat#: 413345 | Name: Corticorelin acetate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Corticorelin acetate is a synthetic form of corticotropin-releasing factor that is currently undergoing clinical trials in the treatment of peritumoral brain edema (PBE).

Chemical Structure

Corticorelin acetate

CAS#86784-80-7

Theoretical Analysis

MedKoo Cat#: 413345

Name: Corticorelin acetate

CAS#: 86784-80-7

Chemical Formula: C208H344N60O63S2

Exact Mass: 0.0000

Molecular Weight: 4757.52

Elemental Analysis: C, 52.51; H, 7.29; N, 17.67; O, 21.19; S, 1.35

Price and Availability

Size	Price	Availability	Quantity
100µg	USD 450.00	2 Weeks

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Synonym

Corticorelin acetate; CCRIS5322; CCRIS-5322; CCRIS 5322

IUPAC/Chemical Name

Corticotropin-releasing factor (sheep), 2-L-glutamic acid-22-L-alanine-23-L-arginine-25-L-glutamic acid-38-L-methionine-39-L-glutamic acid-41-L-isoleucinamide-

InChi Key

GBONBLHJMVUBSJ-FAUHKOHMSA-N

InChi Code

InChI=1S/C208H344N60O63S2/c1-30-106(20)161(165(215)291)263-202(328)163(108(22)32-3)264-184(310)129(58-67-157(285)286)243-182(308)131(70-78-333-29)246-187(313)134(80-99(6)7)250-176(302)118(45-36-37-71-209)237-174(300)120(47-39-73-225-207(218)219)239-194(320)143(89-152(214)276)256-197(323)145(94-270)260-193(319)141(87-115-91-222-96-227-115)248-169(295)112(26)230-172(298)122(51-60-149(211)273)240-177(303)123(52-61-150(212)274)234-168(294)111(25)232-185(311)133(79-98(4)5)249-181(307)124(53-62-151(213)275)241-178(304)125(54-63-153(277)278)235-167(293)110(24)229-171(297)119(46-38-72-224-206(216)217)233-166(292)109(23)231-173(299)130(69-77-332-28)245-179(305)127(56-65-155(281)282)244-188(314)138(84-103(14)15)258-200(326)160(105(18)19)262-183(309)128(57-66-156(283)284)242-175(301)121(48-40-74-226-208(220)221)238-186(312)135(81-100(8)9)251-189(315)136(82-101(10)11)252-192(318)142(88-116-92-223-97-228-116)255-191(317)140(86-114-43-34-33-35-44-114)259-203(329)164(113(27)272)266-196(322)139(85-104(16)17)253-195(321)144(90-159(289)290)257-190(316)137(83-102(12)13)254-198(324)146(95-271)261-201(327)162(107(21)31-2)265-199(325)147-49-41-75-267(147)205(331)148-50-42-76-268(148)204(330)132(59-68-158(287)288)247-180(306)126(55-64-154(279)280)236-170(296)117(210)93-269/h33-35,43-44,91-92,96-113,117-148,160-164,269-272H,30-32,36-42,45-90,93-95,209-210H2,1-29H3,(H2,211,273)(H2,212,274)(H2,213,275)(H2,214,276)(H2,215,291)(H,222,227)(H,223,228)(H,229,297)(H,230,298)(H,231,299)(H,232,311)(H,233,292)(H,234,294)(H,235,293)(H,236,296)(H,237,300)(H,238,312)(H,239,320)(H,240,303)(H,241,304)(H,242,301)(H,243,308)(H,244,314)(H,245,305)(H,246,313)(H,247,306)(H,248,295)(H,249,307)(H,250,302)(H,251,315)(H,252,318)(H,253,321)(H,254,324)(H,255,317)(H,256,323)(H,257,316)(H,258,326)(H,259,329)(H,260,319)(H,261,327)(H,262,309)(H,263,328)(H,264,310)(H,265,325)(H,266,322)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H4,216,217,224)(H4,218,219,225)(H4,220,221,226)/t106-,107-,108-,109-,110-,111-,112-,113+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,160-,161-,162-,163-,164-/m0/s1

SMILES Code

CC[C@@H]([C@@H](C(N)=O)NC([C@H]([C@H](CC)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CCC(O)=O)=O)CCC(O)=O)=O)=O)=O)=O)CO)=O)CC(C)C)=O)CC(O)=O)=O)CC(C)C)=O)=O)Cc3ccccc3)=O)Cc4nc[nH]c4)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CCSC)=O)C)=O)CCCNC(N)=N)=O)C)=O)CCC(O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)C)=O)CCC(N)=O)=O)CCC(N)=O)=O)C)=O)Cc5nc[nH]c5)=O)CO)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CC(C)C)=O)CCSC)=O)CCC(O)=O)=O)=O)C

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM	comments
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 4,757.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Moliterno JA, Henry E, Pannullo SC. Corticorelin acetate injections for the treatment of peritumoral brain edema. Expert Opin Investig Drugs. 2009 Sep;18(9):1413-9. doi: 10.1517/13543780903190689. PMID: 19678803. 2: Gamez I, Ryan RP, Keir ST. Corticorelin acetate, a synthetic corticotropin- releasing factor with preclinical antitumor activity, alone and with bevacizumab, against human brain tumor models. Anticancer Res. 2010 Dec;30(12):5037-42. PMID: 21187487. 3: Gamez I, Ryan RP, Reid LD, Routt SM, Hollister BA. Corticorelin acetate, a synthetic corticotropin-releasing factor with preclinical antitumor activity, alone and with bevacizumab, against human solid tumor models. Cancer Chemother Pharmacol. 2011 Jun;67(6):1415-22. doi: 10.1007/s00280-010-1437-3. Epub 2010 Aug 31. PMID: 20809121. 4: Recht L, Mechtler LL, Wong ET, O'Connor PC, Rodda BE. Steroid-sparing effect of corticorelin acetate in peritumoral cerebral edema is associated with improvement in steroid-induced myopathy. J Clin Oncol. 2013 Mar 20;31(9):1182-7. doi: 10.1200/JCO.2012.43.9455. Epub 2013 Feb 4. PMID: 23382470. 5: Andoh K, Kimura T, Saeki I, Tabata R, Yamazaki S, Eguchi I, Hanazuka M, Horii D, Munt PL, Davis AS, et al. General pharmacological properties of the human corticotropin-releasing hormone corticorelin (human). Arzneimittelforschung. 1994 Jun;44(6):715-26. PMID: 8053970. 6: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2010 Apr;32(3):193-215. doi: 10.1358/mf.2010.32.3.1492017. PMID: 20448862. 7: Roth P, Regli L, Tonder M, Weller M. Tumor-associated edema in brain cancer patients: pathogenesis and management. Expert Rev Anticancer Ther. 2013 Nov;13(11):1319-25. doi: 10.1586/14737140.2013.852473. Epub 2013 Oct 23. PMID: 24152171. 8: Moussaieff A, Gross M, Nesher E, Tikhonov T, Yadid G, Pinhasov A. Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals. J Psychopharmacol. 2012 Dec;26(12):1584-93. doi: 10.1177/0269881112458729. Epub 2012 Sep 26. PMID: 23015543. 9: Moroz MA, Huang R, Kochetkov T, Shi W, Thaler H, de Stanchina E, Gamez I, Ryan RP, Blasberg RG. Comparison of corticotropin-releasing factor, dexamethasone, and temozolomide: treatment efficacy and toxicity in U87 and C6 intracranial gliomas. Clin Cancer Res. 2011 May 15;17(10):3282-92. doi: 10.1158/1078-0432.CCR-10-3203. Epub 2011 Mar 8. PMID: 21385926; PMCID: PMC3131845. 10: Naing KK, Dewar JA, Leese GP. Megestrol acetate therapy and secondary adrenal suppression. Cancer. 1999 Sep 15;86(6):1044-9. PMID: 10491532.