Kuwanon C | CAS#62949-79-5 | Diverse prenylated flavone

MedKoo Cat#: 464057 | Name: Kuwanon C

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kuwanon C is a prenylated flavone originally isolated from M. alba that has diverse biological activities, including antioxidant, antibacterial, antiproliferative, and neuroprotective properties. It scavenges DPPH radicals in a cell-free assay. It is active against E. coli, S. typhimurium, S. epidermis, and S. aureus and inhibits the growth of P388 mouse lymphoma cancer cells. Kuwanon C improves motor coordination in a rotarod test and decreases neuronal loss in the substantia nigra pars compacta in a mouse model of MPTP-induced Parkinson's disease.

Chemical Structure

Kuwanon C

CAS#62949-79-5

Theoretical Analysis

MedKoo Cat#: 464057

Name: Kuwanon C

CAS#: 62949-79-5

Chemical Formula: C25H26O6

Exact Mass: 422.1729

Molecular Weight: 422.48

Elemental Analysis: C, 71.07; H, 6.20; O, 22.72

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 430.00	2 Weeks
25mg	USD 1,190.00	2 Weeks

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Related CAS #

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Synonym

Kuwanon C; Kuwanon-C; Mulberrin;

IUPAC/Chemical Name

2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methylbut-2-en-1-yl)-4H-chromen-4-one

InChi Key

UWQYBLOHTQWSQD-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H26O6/c1-13(2)5-8-17-20(28)12-21(29)22-23(30)18(9-6-14(3)4)24(31-25(17)22)16-10-7-15(26)11-19(16)27/h5-7,10-12,26-29H,8-9H2,1-4H3

SMILES Code

O=C1C2=C(O)C=C(O)C(C/C=C(C)\C)=C2OC(C3=C(C=C(C=C3)O)O)=C1C/C=C(C)\C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Mulberrin (kuwanon C) is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM.

In vitro activity:

This study established a mechanism of action by observing how KC (kuwanon C) prevents the infection of SARS-CoV-2 spike pseudotyped virus in ACE2/TPRSS2-overexpressing HEK293T cells. Finally, this study demonstrated that KC inhibits clinical isolates of SARS-CoV-2 in Vero cells. Reference: Int J Mol Sci. 2022 Oct 19;23(20):12516. https://pubmed.ncbi.nlm.nih.gov/36293371/

In vivo activity:

Mul (mulberrin)-treated mice had an attenuated cardiac injured response and improved cardiac function after DOX (doxorubicin) injection. DOX-induced oxidative damage, inflammation accumulation, and myocardial apoptosis were largely attenuated by the treatment of Mul. Reference: Oxid Med Cell Longev. 2022 Jul 7;2022:2967142. https://pubmed.ncbi.nlm.nih.gov/35847586/

	Solvent	mg/mL	mM
Solubility
	DMSO	100.0	236.70

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 422.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Kim YS, Kwon EB, Kim B, Chung HS, Choi G, Kim YH, Choi JG. Mulberry Component Kuwanon C Exerts Potent Therapeutic Efficacy In Vitro against COVID-19 by Blocking the SARS-CoV-2 Spike S1 RBD:ACE2 Receptor Interaction. Int J Mol Sci. 2022 Oct 19;23(20):12516. doi: 10.3390/ijms232012516. PMID: 36293371; PMCID: PMC9604257. 2. Wen F, Shi M, Bian J, Zhang H, Gui C. Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharm Biol. 2016;54(2):293-302. doi: 10.3109/13880209.2015.1034326. Epub 2015 Apr 10. PMID: 25858254. 3. Ye P, Li WL, Bao LT, Ke W. Mulberrin Confers Protection against Doxorubicin-Induced Cardiotoxicity via Regulating AKT Signaling Pathways in Mice. Oxid Med Cell Longev. 2022 Jul 7;2022:2967142. doi: 10.1155/2022/2967142. PMID: 35847586; PMCID: PMC9283020. 4. Cao W, Dong Y, Zhao W, Lu X, Sun L. Mulberrin attenuates 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced Parkinson's disease by promoting Wnt/β-catenin signaling pathway. J Chem Neuroanat. 2019 Jul;98:63-70. doi: 10.1016/j.jchemneu.2019.04.003. Epub 2019 Apr 9. PMID: 30978489.

In vitro protocol:

In vivo protocol:

1. Ye P, Li WL, Bao LT, Ke W. Mulberrin Confers Protection against Doxorubicin-Induced Cardiotoxicity via Regulating AKT Signaling Pathways in Mice. Oxid Med Cell Longev. 2022 Jul 7;2022:2967142. doi: 10.1155/2022/2967142. PMID: 35847586; PMCID: PMC9283020. 2. Cao W, Dong Y, Zhao W, Lu X, Sun L. Mulberrin attenuates 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced Parkinson's disease by promoting Wnt/β-catenin signaling pathway. J Chem Neuroanat. 2019 Jul;98:63-70. doi: 10.1016/j.jchemneu.2019.04.003. Epub 2019 Apr 9. PMID: 30978489.

1: Zhou J, Li C, Yue Y, Kim YK, Park S. Multitarget Natural Compounds for Ischemic Stroke Treatment: Integration of Deep Learning Prediction and Experimental Validation. J Chem Inf Model. 2025 Apr 14;65(7):3309-3323. doi: 10.1021/acs.jcim.5c00135. Epub 2025 Mar 14. PMID: 40084909. 2: Li Y, Dong M, Qin H, An G, Cen L, Deng L, Cui H. Mulberrin suppresses gastric cancer progression and enhances chemosensitivity to oxaliplatin through HSP90AA1/PI3K/AKT axis. Phytomedicine. 2025 Apr;139:156441. doi: 10.1016/j.phymed.2025.156441. Epub 2025 Jan 28. PMID: 39938178. 3: Schnurr C, Buckett L, Bitenc J, Rychlik M. Quantification of mulberrin and morusin in mulberry and other food plants via stable isotope dilution analysis using LC-MS/MS. Food Chem. 2025 May 1;473:143061. doi: 10.1016/j.foodchem.2025.143061. Epub 2025 Jan 23. PMID: 39892347. 4: Yuan G, Luo Y, Qian P, He N. Mitochondrial Labeling with Mulberrin-Cy3: A New Fluorescent Probe for Live Cell Visualization. Biosensors (Basel). 2024 Sep 5;14(9):428. doi: 10.3390/bios14090428. PMID: 39329803; PMCID: PMC11429601. 5: Gargiulo E, Sirignano C, Arpini S, Ribatti E, Falzoni M, Lembo F, Buommino E, Chianese G, Taglialatela-Scafati O. Untargeted metabolomics profiling of Morus alba twigs extract and antibacterial activity of pure metabolites. Fitoterapia. 2024 Dec;179:106213. doi: 10.1016/j.fitote.2024.106213. Epub 2024 Sep 13. PMID: 39278421. 6: Yuan G, Qian P, Chen L, He N. Kuwanon C Inhibits Tumor Cell Proliferation and Induces Apoptosis by Targeting Mitochondria and Endoplasmic Reticulum. Int J Mol Sci. 2024 Jul 30;25(15):8293. doi: 10.3390/ijms25158293. PMID: 39125863; PMCID: PMC11312418. 7: Qian P, Yuan G, Yang C, Zhang Q, Chen L, He N. Kuwanon C inhibits proliferation and induction of apoptosis via the intrinsic pathway in MDA-MB231 and T47D breast cancer cells. Steroids. 2024 Aug;208:109450. doi: 10.1016/j.steroids.2024.109450. Epub 2024 May 31. PMID: 38823755. 8: Hou J, Ji X, Chu X, Wang B, Sun K, Wei H, Zhang Y, Song Z, Wen F. Mulberry Leaf Dietary Supplementation Can Improve the Lipo-Nutritional Quality of Pork and Regulate Gut Microbiota in Pigs: A Comprehensive Multi-Omics Analysis. Animals (Basel). 2024 Apr 19;14(8):1233. doi: 10.3390/ani14081233. PMID: 38672381; PMCID: PMC11047539. 9: Zhang X, Geng A, Cao D, Dugarjaviin M. Identification of mulberry leaf flavonoids and evaluating their protective effects on H2O2-induced oxidative damage in equine skeletal muscle satellite cells. Front Mol Biosci. 2024 Apr 8;11:1353387. doi: 10.3389/fmolb.2024.1353387. PMID: 38650596; PMCID: PMC11033687. 10: Gao X, Yu J, Zhang L, Shi H, Yan Y, Han Y, Fang M, Liu Y, Wu C, Fan S, Huang C. Mulberrin extends lifespan in Caenorhabditis elegans through detoxification function. J Appl Toxicol. 2024 Jun;44(6):833-845. doi: 10.1002/jat.4578. Epub 2024 Jan 30. PMID: 38291015. 11: Zhang K, Hu X, Su J, Li D, Thakur A, Gujar V, Cui H. Gastrointestinal Cancer Therapeutics via Triggering Unfolded Protein Response and Endoplasmic Reticulum Stress by 2-Arylbenzofuran. Int J Mol Sci. 2024 Jan 13;25(2):999. doi: 10.3390/ijms25020999. PMID: 38256073; PMCID: PMC10816499. 12: Ge C, Tan J, Lou D, Zhu L, Zhong Z, Dai X, Sun Y, Kuang Q, Zhao J, Wang L, Liu J, Wang B, Xu M. Corrigendum to "Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling" [Redox Biol. 51 (2022) 102274]. Redox Biol. 2023 Dec;68:102953. doi: 10.1016/j.redox.2023.102953. Epub 2023 Nov 10. Erratum for: Redox Biol. 2022 May;51:102274. doi: 10.1016/j.redox.2022.102274. PMID: 37949686; PMCID: PMC10719520. 13: Li S, Xie J, Li K, Bai Y, Jiang Z, Xiong X. Mulberrin alleviates triclocarban induced hepatic apoptosis and inflammation by regulating the ROS/NF-κB pathway in grass carp. Comp Biochem Physiol C Toxicol Pharmacol. 2023 Nov;273:109734. doi: 10.1016/j.cbpc.2023.109734. Epub 2023 Sep 4. PMID: 37673375. 14: Škovranová G, Čulenová M, Treml J, Dzurická L, Marova I, Sychrová A. Prenylated phenolics from Morus alba against MRSA infections as a strategy for wound healing. Front Pharmacol. 2022 Nov 30;13:1068371. doi: 10.3389/fphar.2022.1068371. PMID: 36532741; PMCID: PMC9747775. 15: Xu P, Chen Q, Chen X, Qi H, Yang Y, Li W, Yang X, Gunawan A, Chen S, Zhang H, Shen HM, Huang D, Kennedy B, Xu L, Wu Z. Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways. Geroscience. 2023 Apr;45(2):949-964. doi: 10.1007/s11357-022-00693-2. Epub 2022 Dec 3. PMID: 36462128; PMCID: PMC9886792. 16: Kim YS, Kwon EB, Kim B, Chung HS, Choi G, Kim YH, Choi JG. Mulberry Component Kuwanon C Exerts Potent Therapeutic Efficacy In Vitro against COVID-19 by Blocking the SARS-CoV-2 Spike S1 RBD:ACE2 Receptor Interaction. Int J Mol Sci. 2022 Oct 19;23(20):12516. doi: 10.3390/ijms232012516. PMID: 36293371; PMCID: PMC9604257. 17: Lv Q, Lin J, Wu X, Pu H, Guan Y, Xiao P, He C, Jiang B. Novel active compounds and the anti-diabetic mechanism of mulberry leaves. Front Pharmacol. 2022 Oct 5;13:986931. doi: 10.3389/fphar.2022.986931. PMID: 36278175; PMCID: PMC9581293. 18: Chen X, Han Y, Chen L, Tian QL, Yin YL, Zhou Q, Zang SZ, Hou J. Discovery and characterization of the flavonoids in Cortex Mori Radicis as naturally occurring inhibitors against intestinal nitroreductases. Chem Biol Interact. 2022 Dec 1;368:110222. doi: 10.1016/j.cbi.2022.110222. Epub 2022 Oct 14. Erratum in: Chem Biol Interact. 2023 Mar 1;373:110403. doi: 10.1016/j.cbi.2023.110403. PMID: 36244406. 19: Hu J, Hu T, Guo Z, Song Y, Shan L, Shi X. Species Difference in the Metabolism of Mulberrin in Vitro and Its Inhibitory Effect on Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes. Chem Pharm Bull (Tokyo). 2022;70(10):669-678. doi: 10.1248/cpb.c22-00093. PMID: 36184449. 20: Feng F, Xiang W, Gao H, Jia Y, Zhang Y, Zeng L, Chen J, Huang X, Xu L. Rapid Screening of Nonalkaloid α-Glucosidase Inhibitors from a Mulberry Twig Extract Using Enzyme-Functionalized Magnetic Nanoparticles Coupled with UPLC-MS/MS. J Agric Food Chem. 2022 Sep 28;70(38):11958-11966. doi: 10.1021/acs.jafc.2c03435. Epub 2022 Sep 15. PMID: 36107153.