MedKoo Cat#: 413314 | Name: CP 154526

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP 154526 is a potent and selective antagonist of the corticotropin releasing hormone receptor 1 developed by Pfizer. CP-154,526 is under investigation for the potential treatment of alcoholism.

Chemical Structure

CP 154526
CP 154526
CAS#157286-86-7

Theoretical Analysis

MedKoo Cat#: 413314

Name: CP 154526

CAS#: 157286-86-7

Chemical Formula: C23H32N4

Exact Mass: 364.2627

Molecular Weight: 364.54

Elemental Analysis: C, 75.78; H, 8.85; N, 15.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CP 154526; CP-154526; CP154526
IUPAC/Chemical Name
N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo(2,3-d)pyrimidin-4-amine
InChi Key
FHQYJZCJRZHINA-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3
SMILES Code
CC1=C(N2C=C(C)C3=C(N(CCCC)CC)N=C(C)N=C32)C(C)=CC(C)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 364.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kobayashi T, Kiyokawa Y, Takeuchi Y, Mori Y. Pretreatment with CP-154526 blocks the modifying effects of alarm pheromone on components of sexual behavior in male, but not in female, rats. Chem Senses. 2011 Sep;36(7):623-32. doi: 10.1093/chemse/bjr017. Epub 2011 Apr 18. PMID: 21502338. 2: Nalivaiko E, Blessing WW. CRF1-receptor antagonist CP-154526 reduces alerting-related cutaneous vasoconstriction in conscious rabbits. Neuroscience. 2003;117(1):129-38. doi: 10.1016/s0306-4522(02)00818-7. PMID: 12605899. 3: Lawrence KM, Jones RC, Jackson TR, Baylie RL, Abbott B, Bruhn-Olszewska B, Board TN, Locke IC, Richardson SM, Townsend PA. Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1. Sci Rep. 2017 Jul 11;7(1):5147. doi: 10.1038/s41598-017-04367-4. PMID: 28698554; PMCID: PMC5505992. 4: Su J, Tanaka Y, Muratsubaki T, Kano M, Kanazawa M, Fukudo S. Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats. Neurogastroenterol Motil. 2015 Jan;27(1):30-9. doi: 10.1111/nmo.12462. Epub 2014 Oct 31. PMID: 25359531. 5: Zaretsky DV, Zaretskaia MV, Sarkar S, Rusyniak DE, DiMicco JA. The non- peptide CRH1-antagonist CP-154,526 elicits a paradoxical route-dependent activation of the HPA axis. Neurosci Lett. 2017 Jul 13;653:1-6. doi: 10.1016/j.neulet.2017.05.012. Epub 2017 May 13. PMID: 28511913. 6: Navarro-Zaragoza J, Núñez C, Laorden ML, Milanés MV. Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal. Mol Pharmacol. 2010 May;77(5):864-73. doi: 10.1124/mol.109.062463. Epub 2010 Feb 16. PMID: 20159948. 7: Sotomayor-Zárate R, Abarca J, Araya KA, Renard GM, Andrés ME, Gysling K. Exposure to repeated immobilization stress inhibits cocaine-induced increase in dopamine extracellular levels in the rat ventral tegmental area. Pharmacol Res. 2015 Nov;101:116-23. doi: 10.1016/j.phrs.2015.08.015. Epub 2015 Aug 28. PMID: 26318765. 8: Nijsen M, Ongenae N, Meulemans A, Coulie B. Divergent role for CRF1 and CRF2 receptors in the modulation of visceral pain. Neurogastroenterol Motil. 2005 Jun;17(3):423-32. doi: 10.1111/j.1365-2982.2005.00644.x. PMID: 15916630. 9: Seymour PA, Schmidt AW, Schulz DW. The pharmacology of CP-154,526, a non- peptide antagonist of the CRH1 receptor: a review. CNS Drug Rev. 2003 Spring;9(1):57-96. doi: 10.1111/j.1527-3458.2003.tb00244.x. PMID: 12595912; PMCID: PMC6741649. 10: Schwetz I, Bradesi S, McRoberts JA, Sablad M, Miller JC, Zhou H, Ohning G, Mayer EA. Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors. Am J Physiol Gastrointest Liver Physiol. 2004 Apr;286(4):G683-91. doi: 10.1152/ajpgi.00358.2003. Epub 2003 Nov 13. PMID: 14615283.