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MedKoo Cat#: 413309 | Name: Piroxicam olamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piroxicam olamine is a cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.

Chemical Structure

Piroxicam olamine
Piroxicam olamine
CAS#85056-47-9 (olamine)

Theoretical Analysis

MedKoo Cat#: 413309

Name: Piroxicam olamine

CAS#: 85056-47-9 (olamine)

Chemical Formula: C17H20N4O5S

Exact Mass: 392.1154

Molecular Weight: 392.43

Elemental Analysis: C, 52.03; H, 5.14; N, 14.28; O, 20.38; S, 8.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
87234-24-0 (cinnamate); 85056-47-9 (olamine); 36322-90-4 (free base); 96684-40-1 (betadex)
Synonym
Piroxicam olamine; CP16171-85; CP-16171-85; CP 16171-85
IUPAC/Chemical Name
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-,1,1-dioxide, compd with 2-aminoethanol (1:1)
InChi Key
FVTSYHPRVGNAQI-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13N3O4S.C2H7NO/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22;3-1-2-4/h2-9,19H,1H3,(H,16,17,20);4H,1-3H2
SMILES Code
O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NC=CC=C3.NCCO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 392.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gwak HS, Choi JS, Choi HK. Enhanced bioavailability of piroxicam via salt formation with ethanolamines. Int J Pharm. 2005 Jun 13;297(1-2):156-61. doi: 10.1016/j.ijpharm.2005.03.016. Epub 2005 Apr 25. PMID: 15907602. 2: Cheong HA, Choi HK. Enhanced percutaneous absoption of piroxicam via salt formation with ethanolamines. Pharm Res. 2002 Sep;19(9):1375-80. doi: 10.1023/a:1020367212307. PMID: 12403076. 3: Cheong HA, Choi HK. Effect of ethanolamine salts and enhancers on the percutaneous absorption of piroxicam from a pressure sensitive adhesive matrix. Eur J Pharm Sci. 2003 Feb;18(2):149-53. doi: 10.1016/s0928-0987(02)00254-3. PMID: 12594008. 4: Rockwell CE, Kaminski NE. A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J Pharmacol Exp Ther. 2004 Nov;311(2):683-90. doi: 10.1124/jpet.104.065524. Epub 2004 Jul 29. PMID: 15284281. 5: Ki HM, Choi HK. The effect of meloxicam/ethanolamine salt formation on percutaneous absorption of meloxicam. Arch Pharm Res. 2007 Feb;30(2):215-21. doi: 10.1007/BF02977697. PMID: 17366744.