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MedKoo Cat#: 413304 | Name: Perindopril arginine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Perindopril arginine is an angiotensin converting enzyme inhibitor, and amlodipine, a dihydropyridine calcium channel blocker, and is indicated for the treatment of hypertension, to lower blood pressure.

Chemical Structure

Perindopril arginine
CAS#612548-45-5

Theoretical Analysis

MedKoo Cat#: 413304

Name: Perindopril arginine

CAS#: 612548-45-5

Chemical Formula: C25H46N6O7

Exact Mass: 542.3428

Molecular Weight: 542.68

Elemental Analysis: C, 55.33; H, 8.54; N, 15.49; O, 20.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Perindopril arginine; Coversyl; Perindopril L-arginine
IUPAC/Chemical Name
L-Arginine, (2S,3aS,7aS)-1-((2S)-2-(((1S)-1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylate (1:1)
InChi Key
RYCSJJXKEWBUTI-YDYAIEMNSA-N
InChi Code
InChI=1S/C19H32N2O5.C6H14N4O2/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24;7-4(5(11)12)2-1-3-10-6(8)9/h12-16,20H,4-11H2,1-3H3,(H,23,24);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t12-,13-,14-,15-,16-;4-/m00/s1
SMILES Code
N[C@@H](CCCNC(N)=N)C(O)=O.O=C([C@H]1N(C([C@@H](N[C@H](C(OCC)=O)CCC)C)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 542.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Elliott WJ, Bistrika EA. Perindopril arginine and amlodipine besylate for hypertension: a safety evaluation. Expert Opin Drug Saf. 2018 Feb;17(2):207-216. doi: 10.1080/14740338.2018.1397129. Epub 2017 Oct 31. PMID: 29065722. 2: Shirley M, McCormack PL. Perindopril/amlodipine (Prestalia(®)): a review in hypertension. Am J Cardiovasc Drugs. 2015 Oct;15(5):363-70. doi: 10.1007/s40256-015-0144-1. PMID: 26341621. 3: Glezer MG; FORSAGE Investigators. Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study. Cardiol Ther. 2020 Jun;9(1):139-152. doi: 10.1007/s40119-020-00162-x. Epub 2020 Feb 1. PMID: 32008207; PMCID: PMC7237592. 4: Telejko E. Perindopril arginine: benefits of a new salt of the ACE inhibitor perindopril. Curr Med Res Opin. 2007 May;23(5):953-60. doi: 10.1185/030079907x182158. PMID: 17519062. 5: Gach O, Falque B, Canivet A, Krzesinski F, Krzesinski JM, Lancellotti P. Le médicament du mois BIPRESSIL® : Première association fixe bisoprolol et perindopril arginine [Bipressil® : first single-pill combination of bisoprolol and perindopril arginine]. Rev Med Liege. 2017 May;72(5):260-265. French. PMID: 28520326. 6: Elliott WJ. Rationale for a single-pill combination of perindopril arginine and amlodipine besylate. J Am Soc Hypertens. 2015 Apr;9(4):257-65. doi: 10.1016/j.jash.2014.12.012. Epub 2015 Jan 12. PMID: 25817217. 7: Al-Tannak NF. UHPLC-UV Method for Simultaneous Determination of Perindopril Arginine and Indapamide Hemihydrate in Combined Dosage Form: A Stability- Indicating Assay Method. Sci Pharm. 2018 Feb 22;86(1):7. doi: 10.3390/scipharm86010007. PMID: 29470453; PMCID: PMC5874537. 8: Borisova EV, Kochetkov AI, Ostroumova OD. [Single Pill Indapamide and Perindopril Arginine Combination: Optimal Coupling of Vascular Protection and Hemodynamic Risk Factors Reduction in Patients with Essential Arterial Hypertension]. Kardiologiia. 2019 Apr 12;59(3):18-26. Russian. doi: 10.18087/cardio.2019.3.10236. PMID: 30990137. 9: Elliott WJ. Perindopril arginine + amlodipine for the treatment of hypertension in the USA. Expert Opin Pharmacother. 2015;16(14):2217-29. doi: 10.1517/14656566.2015.1083978. Epub 2015 Sep 1. PMID: 26325023. 10: Remko M. Molecular structure and stability of perindopril erbumine and perindopril L-arginine complexes. Eur J Med Chem. 2009 Jan;44(1):101-8. doi: 10.1016/j.ejmech.2008.03.012. Epub 2008 Mar 27. PMID: 18436349.

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