NIP-121 | CAS#unknown | Antihypertensive agent

MedKoo Cat#: 464030 | Name: NIP-121

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NIP-121 is an antihypertensive agent.

Chemical Structure

NIP-121

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464030

Name: NIP-121

CAS#: unknown

Chemical Formula: C16H19N3O4

Exact Mass: 317.1376

Molecular Weight: 317.35

Elemental Analysis: C, 60.56; H, 6.04; N, 13.24; O, 20.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NIP-121; NIP121; NIP 121;

IUPAC/Chemical Name

1-((7S,8R)-7-hydroxy-6,6-dimethyl-7,8-dihydro-6H-chromeno[6,7-c][1,2,5]oxadiazol-8-yl)piperidin-2-one

InChi Key

KMXPHBJUGYLXDM-CABCVRRESA-N

InChi Code

InChI=1S/C16H19N3O4/c1-16(2)15(21)14(19-6-4-3-5-13(19)20)9-7-10-11(18-23-17-10)8-12(9)22-16/h7-8,14-15,21H,3-6H2,1-2H3/t14-,15+/m1/s1

SMILES Code

CC1(C)OC2=CC3=NON=C3C=C2[C@@H](N4CCCCC4=O)[C@@H]1O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM	comments
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 317.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Namekata I, Yamaguchi Y, Moriguchi S, Yamazaki S, Terasawa A, Yamagishi R, Aikawa T, Saito T, Kurashima K, Seri K, Imamura Y, Akita H, Shigenobu K, Tanaka H. (R)-ACX, a pancreatic beta-cell selective sulfonylurea, does not aggravate myocardial ischemia-reperfusion damage. Eur J Pharmacol. 2007 Dec 22;577(1-3):211-8. doi: 10.1016/j.ejphar.2007.09.012. Epub 2007 Sep 26. PMID: 17927975. 2: Tanaka Y, Igarashi T, Kaneko H, Yamaki F, Mochizuki Y, Aida M, Taniguchi H, Tanaka H, Shigenobu K. NO-mediated MaxiK(Ca) channel activation produces relaxation of guinea pig aorta independently of voltage-dependent L-type Ca(2+) channels. Gen Pharmacol. 2000 Mar;34(3):159-65. doi: 10.1016/s0306-3623(00)00056-2. PMID: 11120377. 3: Tanaka Y, Yamaki F, Hirano H, Otsuka A, Tanaka H, Shigenobu K. Endothelium is involved in the vasorelaxation by an ATP-sensitive K+ channel opener, NIP-121. Eur J Pharmacol. 1999 Feb 5;366(2-3):R9-10. doi: 10.1016/s0014-2999(98)00960-1. PMID: 10082219. 4: Muramatsu M, Oka M, Morio Y, Soma S, Takahashi H, Fukuchi Y. Chronic hypoxia augments endothelin-B receptor-mediated vasodilation in isolated perfused rat lungs. Am J Physiol. 1999 Feb;276(2):L358-64. doi: 10.1152/ajplung.1999.276.2.L358. PMID: 9950899. 5: Saito W, Aida M, Sasaki M, Saito Y, Tanaka Y, Tanaka H, Shigenobu K. Differential sensitivity to ATP-sensitive potassium channel openers of norepinephrine-induced contraction of guinea pig and rat aorta. Life Sci. 1998;62(24):2171-9. doi: 10.1016/s0024-3205(98)00194-5. PMID: 9627075. 6: Saito W, Noguchi K, Okazaki K, Matsuda T, Kato Y, Tanaka H, Shigenobu K. Temperature-sensitive effects of potassium channel openers on isolated guinea pig myocardium and aorta. J Cardiovasc Pharmacol. 1998 Feb;31(2):327-9. doi: 10.1097/00005344-199802000-00021. PMID: 9475277. 7: Tanaka H, Okazaki K, Shigenobu K. Cardioprotective effects of NIP-121, a novel ATP-sensitive potassium channel opener, during ischemia and reperfusion in coronary perfused guinea pig myocardium. J Cardiovasc Pharmacol. 1996 May;27(5):695-701. doi: 10.1097/00005344-199605000-00012. PMID: 8859940. 8: Shikada K, Tanaka S. Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea. Prostaglandins. 1996 May;51(5):351-61. doi: 10.1016/0090-6980(96)00027-5. Erratum in: Prostaglandins 1996 Oct;52(4):339. PMID: 8792445. 9: Matsuda T, Okazaki K, Kato Y, Tanaka H, Shigenobu K. K+ channel-opening properties of a novel compound, NIP-121, in guinea pig myocardium as compared with those of cromakalim. J Cardiovasc Pharmacol. 1995 Oct;26(4):608-13. doi: 10.1097/00005344-199510000-00016. PMID: 8569223. 10: Shikada K, Tanaka S. K+ channel openers produce epithelium-dependent relaxation of the guinea-pig trachea. Eur J Pharmacol. 1995 Aug 25;282(1-3):193-7. doi: 10.1016/0014-2999(95)00328-i. PMID: 7498276. 11: Yamashita T, Masuda Y, Kawamura N, Fujikura N, Tanaka S. Comparative study of vasodilator effects of the potassium channel openers NIP-121 and levcromakalim in dogs and rats. Jpn J Pharmacol. 1995 Jun;68(2):145-52. doi: 10.1254/jjp.68.145. PMID: 7563971. 12: Yamashita T, Masuda Y, Tanaka S. The effects of potassium channel openers and blockers on the specific binding sites for [3H]glibenclamide in rat tissues. Jpn J Pharmacol. 1995 Jan;67(1):35-44. doi: 10.1254/jjp.67.35. PMID: 7745843. 13: Yamashita T, Masuda Y, Tanaka S. Potassium channel openers relax A23187-induced nifedipine-resistant contraction of rat aorta. J Cardiovasc Pharmacol. 1994 Dec;24(6):914-20. doi: 10.1097/00005344-199424060-00008. PMID: 7898074. 14: Yamashita T, Masuda Y, Tanaka S. Inhibitory properties of NIP-121, a potassium channel opener, on high potassium- and norepinephrine-induced contraction and calcium mobilization in rat aorta. J Cardiovasc Pharmacol. 1994 Dec;24(6):890-5. PMID: 7898070. 15: Oka M, Morris KG, McMurtry IF. NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension. J Appl Physiol (1985). 1993 Sep;75(3):1075-80. doi: 10.1152/jappl.1993.75.3.1075. PMID: 8226514. 16: Shikada K, Tanaka S. Influence of epithelium on the inhibition of melittin- induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121. Br J Pharmacol. 1993 Aug;109(4):1091-6. doi: 10.1111/j.1476-5381.1993.tb13734.x. PMID: 8401920; PMCID: PMC2175738. 17: Shikada K, Tanaka S. Potassium channel openers, NIP-121 and cromakalim, enhance the relaxation induced by sodium nitroprusside in the guinea-pig isolated trachea. Br J Pharmacol. 1992 Dec;107(4):1116-20. doi: 10.1111/j.1476-5381.1992.tb13416.x. PMID: 1334750; PMCID: PMC1907935. 18: Yamamoto A, Shikada K, Tanaka S. Effects of anti-asthma drugs and potassium channel openers on neurally-mediated contraction of isolated guinea pig trachea. Jpn J Pharmacol. 1992 May;59(1):129-32. doi: 10.1254/jjp.59.129. PMID: 1507653. 19: Shikada K, Yamamoto A, Tanaka S. Modulation of guinea-pig tracheal smooth muscle responsiveness by the potassium channel openers NIP-121 and cromakalim. Jpn J Pharmacol. 1992;58 Suppl 2:334P. PMID: 1507583. 20: Shikada K, Yamamoto A, Tanaka S. NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea- pig isolated trachea. Eur J Pharmacol. 1991 Dec 10;209(1-2):69-73. doi: 10.1016/0014-2999(91)90012-f. PMID: 1814761.