Tetrahydrocorticosterone | CAS#68-42-8 | Anti-inflammatory glucocorticoid

MedKoo Cat#: 464020 | Name: Tetrahydrocorticosterone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tetrahydrocorticosterone (THB) is a glucocorticoid (GC) that has anti-inflammatory functions. For instance, 5α THB inhibits inflammatory actions by binding to GC receptor. HPLC studies in rat brains have reported that tetrahydrocorticosterone (THB) isomers are differentially distributed in males and females.

Chemical Structure

Tetrahydrocorticosterone

CAS#68-42-8

Theoretical Analysis

MedKoo Cat#: 464020

Name: Tetrahydrocorticosterone

CAS#: 68-42-8

Chemical Formula: C21H34O4

Exact Mass: 350.2457

Molecular Weight: 350.50

Elemental Analysis: C, 71.96; H, 9.78; O, 18.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Tetrahydrocorticosterone; THB;

IUPAC/Chemical Name

1-((3R,5R,8S,9S,10S,11S,13S,14S,17S)-3,11-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-hydroxyethan-1-one

InChi Key

RHQQHZQUAMFINJ-DTDWNVJFSA-N

InChi Code

InChI=1S/C21H34O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12-17,19,22-24H,3-11H2,1-2H3/t12-,13-,14+,15+,16-,17+,19-,20+,21+/m1/s1

SMILES Code

C[C@]12CC[C@H](C[C@H]1CC[C@H]3[C@@H]4CC[C@@H]([C@]4(C[C@@H]([C@H]23)O)C)C(CO)=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM	comments
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 350.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message Sent On: Fri Feb 12 14:30:59 2021 Search: Tetrahydrocorticosterone 20 selected items PubMed Results Items 1-20 of 20 (Display the 20 citations in PubMed) 1: Zhao M, Xing Y, Liu L, Fan X, Liu L, Geng T, Gong D. GC-TOF-MS-Based Metabolomics Analyses of Liver and Intestinal Contents in the Overfed vs. Normally-Fed Geese. Animals (Basel). 2020 Dec 11;10(12):2375. doi: 10.3390/ani10122375. PMID: 33322323; PMCID: PMC7763799. 2: Sze Y, Brunton PJ. Effects of prenatal stress on neuroactive steroid responses to acute stress in adult male and female rats. J Neuroendocrinol. 2021 Jan;33(1):e12916. doi: 10.1111/jne.12916. Epub 2020 Dec 3. PMID: 33270955. 3: Wang Q, Shimizu K, Maehata K, Pan Y, Sakurai K, Hikida T, Fukada Y, Takao T. 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