Varioxepine A | CAS#1623451-72-8 | Fungal metabolite

MedKoo Cat#: 464016 | Name: Varioxepine A

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Varioxepine A is a fungal metabolite originally isolated from P. variotii. It is active against the plant pathogenic fungus F. graminearum.

Chemical Structure

Varioxepine A

CAS#1623451-72-8

Theoretical Analysis

MedKoo Cat#: 464016

Name: Varioxepine A

CAS#: 1623451-72-8

Chemical Formula: C26H29N3O5

Exact Mass: 463.2107

Molecular Weight: 463.53

Elemental Analysis: C, 67.37; H, 6.31; N, 9.07; O, 17.26

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 950.00	2 Weeks

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Related CAS #

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Synonym

Varioxepine A; Varioxepine-A;

IUPAC/Chemical Name

(3R,5aR,15S,16aS)-15-benzyl-12-isopropyl-2,2-dimethyl-3,4-dihydro-2H,13H-3,16a-epoxy[1,4]dioxepino[2,3-e]oxepino[2,3-d]pyrazino[1,2-a]pyrimidin-14(15H)-one

InChi Key

PZRCCRWGGJKTKC-GZLQHJCCSA-N

InChi Code

InChI=1S/C26H29N3O5/c1-16(2)20-21-28-23-25(12-8-9-13-31-23)26(33-19(15-32-25)24(3,4)34-26)29(21)18(22(30)27-20)14-17-10-6-5-7-11-17/h5-13,16,18-19H,14-15H2,1-4H3,(H,27,30)/t18-,19+,25+,26-/m0/s1

SMILES Code

CC(C(NC1=O)=C2N=C3OC=CC=C[C@@]34OC[C@@H]5C(O[C@@]4(N2[C@H]1CC6=CC=CC=C6)O5)(C)C)C

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 463.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wu Q, Wu C, Long H, Chen R, Liu D, Proksch P, Guo P, Lin W. Varioxiranols A-G and 19-O-Methyl-22-methoxypre-shamixanthone, PKS and Hybrid PKS-Derived Metabolites from a Sponge-Associated Emericella variecolor Fungus. J Nat Prod. 2015 Oct 23;78(10):2461-70. doi: 10.1021/acs.jnatprod.5b00578. Epub 2015 Sep 22. PMID: 26394166. 2: Zhang P, Mándi A, Li XM, Du FY, Wang JN, Li X, Kurtán T, Wang BG. Varioxepine A, a 3H-oxepine-containing alkaloid with a new oxa-cage from the marine algal- derived endophytic fungus Paecilomyces variotii. Org Lett. 2014 Sep 19;16(18):4834-7. doi: 10.1021/ol502329k. Epub 2014 Aug 28. PMID: 25167167.