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MedKoo Cat#: 413259 | Name: Stercuronium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Stercuronium is an aminosteroid neuromuscular blocking agent which was never marketed. It acts as a competitive antagonist of the nicotinic acetylcholine receptor, and is also reported to be an acetylcholinesterase inhibitor.

Chemical Structure

Stercuronium
Stercuronium
CAS# 734477-69-1

Theoretical Analysis

MedKoo Cat#: 413259

Name: Stercuronium

CAS#: 734477-69-1

Chemical Formula: C26H43N2+

Exact Mass: 383.3421

Molecular Weight: 383.64

Elemental Analysis: C, 81.40; H, 11.30; N, 7.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Stercuronium; Stercuronium ion; Stercuronium cation
IUPAC/Chemical Name
(3S,3aS,5aS,5bR,9S,11aR,11bS,13aR)-N-ethyl-N,N,2,3,11a-pentamethyl-2,3,3a,4,5,5a,5b,9,10,11,11a,11b,12,13-tetradecahydro-1H-naphtho[2',1':4,5]indeno[1,7a-c]pyrrol-9-aminium
InChi Key
GGXDVUAOXCBCBN-HJZGYWQISA-N
InChi Code
InChI=1S/C26H43N2/c1-7-28(5,6)20-12-14-25(3)19(16-20)8-9-21-23(25)13-15-26-17-27(4)18(2)22(26)10-11-24(21)26/h8-9,16,18,20-24H,7,10-15,17H2,1-6H3/q+1/t18-,20-,21+,22+,23-,24-,25-,26-/m0/s1
SMILES Code
CC[N+](C)([C@H]1CC[C@@]2([C@H]3CC[C@]45CN([C@H]([C@H]4CC[C@H]5[C@@H]3C=CC2=C1)C)C)C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 383.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li CK, Mitchelson F. The selective antimuscarinic action of stercuronium. Br J Pharmacol. 1980 Oct;70(2):313-21. doi: 10.1111/j.1476-5381.1980.tb07938.x. PMID: 6893558; PMCID: PMC2044327. 2: Raiteri M, Leardi R, Marchi M. Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain. J Pharmacol Exp Ther. 1984 Jan;228(1):209-14. PMID: 6141277. 3: Clague RU, Eglen RM, Strachan AC, Whiting RL. Action of agonists and antagonists at muscarinic receptors present on ileum and atria in vitro. Br J Pharmacol. 1985 Sep;86(1):163-70. doi: 10.1111/j.1476-5381.1985.tb09446.x. PMID: 3876860; PMCID: PMC1916877. 4: Brown DA, Forward A, Marsh S. Antagonist discrimination between ganglionic and ileal muscarinic receptors. Br J Pharmacol. 1980;71(2):362-4. doi: 10.1111/j.1476-5381.1980.tb10948.x. PMID: 7470751; PMCID: PMC2044477. 5: Li CK, Mitchelson F. The effect of stercuronium on cardiac muscarinic receptors. Eur J Pharmacol. 1978 Oct 1;51(3):251-9. PMID: 581375. 6: Hespe W, Wieriks J. Metabolic fate of the short-acting peripheral neuromuscular blocking agent stercuronium in the rat, as related to its action. Biochem Pharmacol. 1971 Jun;20(6):1213-24. doi: 10.1016/0006-2952(71)90351-0. PMID: 5118118. 7: Choo LK, Mitchelson F, Vong YM. The interaction of McN-A-343 with pirenzepine and other selective muscarine receptor antagonists at a prejunctional muscarine receptor. Naunyn Schmiedebergs Arch Pharmacol. 1985 Feb;328(4):430-8. doi: 10.1007/BF00692912. PMID: 2581148. 8: Mitchelson FJ. The interaction of nicotinic receptor antagonists at muscarinic receptors. Clin Exp Pharmacol Physiol. 1987 May;14(5):385-91. doi: 10.1111/j.1440-1681.1987.tb00988.x. PMID: 3677483. 9: Li CK, Mitchelson F. Effect of variations in temperature on antimuscarinic activity in guinea-pig atria. Experientia. 1978 May 15;34(5):641-3. doi: 10.1007/BF01937009. PMID: 658257. 10: Brown DA, Forward A, Marsh S. Antagonist discrimination between ganglionic and ileal muscarinic receptors. 1980. Br J Pharmacol. 1997 Feb;120(4 Suppl):447-9; discussion 444-6. doi: 10.1111/j.1476-5381.1997.tb06833.x. PMID: 9142423; PMCID: PMC3224328.