Synonym
Aquastatin A; Aquastatin-A;
IUPAC/Chemical Name
2-hydroxy-4-((2-hydroxy-6-pentadecyl-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzoyl)oxy)-6-methylbenzoic acid
InChi Key
PAQGKQJWHLLQLF-DIARTVEHSA-N
InChi Code
InChI=1S/C36H52O12/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-23-18-25(47-36-33(42)32(41)31(40)28(21-37)48-36)20-27(39)30(23)35(45)46-24-17-22(2)29(34(43)44)26(38)19-24/h17-20,28,31-33,36-42H,3-16,21H2,1-2H3,(H,43,44)/t28-,31+,32+,33-,36-/m1/s1
SMILES Code
CC1=C(C(O)=O)C(O)=CC(OC(C2=C(CCCCCCCCCCCCCCC)C=C(O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)C=C2O)=O)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
676.80
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kwon YJ, Fang Y, Xu GH, Kim WG. Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611. Biol Pharm Bull. 2009 Dec;32(12):2061-4. doi: 10.1248/bpb.32.2061. PMID: 19952429.
2: Seo C, Sohn JH, Oh H, Kim BY, Ahn JS. Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6095-7. doi: 10.1016/j.bmcl.2009.09.025. Epub 2009 Sep 12. PMID: 19782562.
3: Ondeyka JG, Zink DL, Dombrowski AW, Polishook JD, Felock PJ, Hazuda DJ, Singh SB. Isolation, structure and HIV-1 integrase inhibitory activity of exophillic acid, a novel fungal metabolite from Exophiala pisciphila. J Antibiot (Tokyo). 2003 Dec;56(12):1018-23. doi: 10.7164/antibiotics.56.1018. PMID: 15015729.
4: Hamano K, Kinoshita-Okami M, Minagawa K, Haruyama H, Kinoshita T, Hosoya T, Furuya K, Kinoshita K, Tabata K, Hemmi A, et al. Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties. J Antibiot (Tokyo). 1993 Nov;46(11):1648-57. doi: 10.7164/antibiotics.46.1648. PMID: 8270486.
