MedKoo Cat#: 413232 | Name: Coleneuramide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Coleneuramide is a neuroprotective agent used in treatment of Diabetic Neuropathy

Chemical Structure

Coleneuramide
CAS#204200-47-5

Theoretical Analysis

MedKoo Cat#: 413232

Name: Coleneuramide

CAS#: 204200-47-5

Chemical Formula: C39H68N2O8

Exact Mass: 692.4976

Molecular Weight: 692.98

Elemental Analysis: C, 67.60; H, 9.89; N, 4.04; O, 18.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Coleneuramide; MCC257; MCC 257; MCC-257
IUPAC/Chemical Name
(2R,4S,5R,6R)-5-acetamido-N-((3R,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-4-hydroxy-2-methoxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxamide
InChi Key
CHMRTBYTCBDIRG-JQZMMWJVSA-N
InChi Code
InChI=1S/C39H68N2O8/c1-22(2)9-8-10-23(3)28-13-14-29-27-12-11-25-19-26(15-17-37(25,5)30(27)16-18-38(28,29)6)41-36(47)39(48-7)20-31(44)33(40-24(4)43)35(49-39)34(46)32(45)21-42/h22-23,25-35,42,44-46H,8-21H2,1-7H3,(H,40,43)(H,41,47)/t23-,25+,26-,27+,28-,29+,30+,31+,32-,33-,34-,35-,37+,38-,39-/m1/s1
SMILES Code
CO[C@]1(C(N[C@@H]2CC[C@]3([C@H](C2)CC[C@H]4[C@@H]5CC[C@@H]([C@]5(CC[C@H]34)C)[C@@H](CCCC(C)C)C)C)=O)C[C@@H]([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O1)NC(C)=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 692.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yamada MK, Konishi Y, Kakinoki B, Ikegami K, Setou M. Enhancement of Trk signaling pathways by the cholestane amide conjugate MCC-257. J Pharmacol Sci. 2008 Sep;108(1):131-4. doi: 10.1254/jphs.08109sc. Epub 2008 Aug 30. PMID: 18758136. 2: Kakinoki B, Sekimoto S, Yuki S, Ohgami T, Sejima M, Yamagami K, Saito K. Orally active neurotrophin-enhancing agent protects against dysfunctions of the peripheral nerves in hyperglycemic animals. Diabetes. 2006 Mar;55(3):616-21. doi: 10.2337/diabetes.55.03.06.db05-1091. PMID: 16505223. 3: Fujimura M, Usuki F. Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: in vitro and in vivo effects of TrkA pathway activators. Toxicol Appl Pharmacol. 2015 Feb 1;282(3):259-66. doi: 10.1016/j.taap.2014.12.008. Epub 2014 Dec 26. PMID: 25545984.