MedKoo Cat#: 463993 | Name: ML-106

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML-106 is a quinazoline-based CLK inhibitor.

Chemical Structure

ML-106
ML-106
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463993

Name: ML-106

CAS#: unknown

Chemical Formula: C20H15N3O2S

Exact Mass: 361.0885

Molecular Weight: 361.42

Elemental Analysis: C, 66.47; H, 4.18; N, 11.63; O, 8.85; S, 8.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ML-106; ML106; ML 106;
IUPAC/Chemical Name
6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine
InChi Key
QFBOPHGXTBOQRN-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H15N3O2S/c1-2-15(26-7-1)10-21-20-16-8-13(3-5-17(16)22-11-23-20)14-4-6-18-19(9-14)25-12-24-18/h1-9,11H,10,12H2,(H,21,22,23)
SMILES Code
C1(C2=CC3=C(NCC4=CC=CS4)N=CN=C3C=C2)=CC(OCO5)=C5C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 361.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim SY, Lee SH, Shin JS, Lee D, Lee T, Park KC, Min KH, Kim DS. A derivative of imidazobenzimidazole, ML106, inhibits melanin synthesis via p38 MAPK activation. Pharmazie. 2014 May;69(5):353-7. PMID: 24855826. 2: Auld D, Shen M, Thomas C. A high-throughput screen for pre-mRNA splicing modulators. 2009 May 18 [updated 2010 Sep 2]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 21433360.