Synonym
CM 57493; CM-57493; CM57493
IUPAC/Chemical Name
1(2H)-Pyridinepropanenitrile, 3,6-dihydro-4-(3-(trifluoromethyl)phenyl)-
InChi Key
XVBCZSYHUGVSIB-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H15F3N2/c16-15(17,18)14-4-1-3-13(11-14)12-5-9-20(10-6-12)8-2-7-19/h1,3-5,11H,2,6,8-10H2
SMILES Code
N#CCCN1CC=C(C2=CC=CC(C(F)(F)F)=C2)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
280.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Adrien J, Lanfumey L, Gozlan H, Fattaccini CM, Hamon M. Biochemical and electrophysiological evidence for an agonist action of CM 57493 at pre- and postsynaptic 5-hydroxytryptamine1A receptors in brain. J Pharmacol Exp Ther. 1989 Mar;248(3):1222-30. PMID: 2522986.
2: Prehn JH, Backhauss C, Karkoutly C, Nuglisch J, Peruche B, Rossberg C, Krieglstein J. Neuroprotective properties of 5-HT1A receptor agonists in rodent models of focal and global cerebral ischemia. Eur J Pharmacol. 1991 Oct 15;203(2):213-22. doi: 10.1016/0014-2999(91)90717-5. PMID: 1800118.
3: Roncucci R, Miranda GF, Verry M. Two novel agents affecting eating through an action on monoaminergic systems. Int J Obes. 1984;8 Suppl 1:103-17. PMID: 6549508.
4: Peruche B, Backhauss C, Prehn JH, Krieglstein J. Protective effects of 5-HT1A receptor agonists against neuronal damage demonstrated in vivo and in vitro. J Neural Transm Park Dis Dement Sect. 1994;8(1-2):73-83. doi: 10.1007/BF02250918. PMID: 7893378.
5: Prehn JH, Welsch M, Backhauss C, Nuglisch J, Ausmeier F, Karkoutly C, Krieglstein J. Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia. Brain Res. 1993 Dec 10;630(1-2):10-20. doi: 10.1016/0006-8993(93)90636-2. PMID: 8118677.
6: Garattini S, Mennini T, Bendotti C, Invernizzi R, Samanin R. Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system. Appetite. 1986;7 Suppl:15-38. doi: 10.1016/s0195-6663(86)80050-2. PMID: 2427023.
