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MedKoo Cat#: 413196 | Name: Cloxacepride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cloxacepride is a calcium channel blocker.

Chemical Structure

Cloxacepride
Cloxacepride
CAS#65569-29-1

Theoretical Analysis

MedKoo Cat#: 413196

Name: Cloxacepride

CAS#: 65569-29-1

Chemical Formula: C22H27Cl2N3O4

Exact Mass: 467.1379

Molecular Weight: 468.38

Elemental Analysis: C, 56.42; H, 5.81; Cl, 15.14; N, 8.97; O, 13.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cloxacepride; Cloxacepridum; Cloxaceprida
IUPAC/Chemical Name
5-Chloro-4-(2-(p-chlorophenoxy)acetamido)-N-(2-(diethylamino)ethyl)-o-anisamide
InChi Key
VZNJZQAFQDEJOO-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H27Cl2N3O4/c1-4-27(5-2)11-10-25-22(29)17-12-18(24)19(13-20(17)30-3)26-21(28)14-31-16-8-6-15(23)7-9-16/h6-9,12-13H,4-5,10-11,14H2,1-3H3,(H,25,29)(H,26,28)
SMILES Code
COC1=CC(NC(COC2=CC=C(Cl)C=C2)=O)=C(Cl)C=C1C(NCCN(CC)CC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 468.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schmutzler W, Greven T, Braam U. The effects of metoclopramide and cloxacepride on human mast cells from adenoidal tissues. Agents Actions. 1989 Apr;27(1-2):110-2. doi: 10.1007/BF02222213. PMID: 2473615. 2: Metz G, Pindell MH, Chen HL. Cloxacepride and related compounds: a new series of orally active antiallergic compounds. J Med Chem. 1983 Jul;26(7):1065-70. doi: 10.1021/jm00361a022. PMID: 6134832. 3: Friedrich G, Haas R, Metz G. Inhibitory effect of cloxacepride on compound 48/80-induced histamine and serotonin release from rat mast cells. Arch Int Pharmacodyn Ther. 1984 Feb;267(2):264-8. PMID: 6201147. 4: Gigl G, Hartweg D, Sanchez-Delgado E, Metz G, Gietzen K. Calmodulin antagonism: a pharmacological approach for the inhibition of mediator release from mast cells. Cell Calcium. 1987 Oct;8(5):327-44. doi: 10.1016/0143-4160(87)90008-x. PMID: 2448039. 5: Drozd MP, Gietzen K. Effects of the novel dihydropyridine derivative niguldipine on the cytoplasmic free calcium concentration of mouse thymocytes. Biochem Pharmacol. 1990 Sep 1;40(5):955-9. doi: 10.1016/0006-2952(90)90479-5. PMID: 2390115.