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MedKoo Cat#: 463967 | Name: Clobetasol Propionate-d5
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid. It binds to glucocorticoid receptors in a cell-free assay and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml. Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice. Formulations containing clobetasol propionate have been used in the treatment of inflammatory skin conditions.

Chemical Structure

Clobetasol Propionate-d5
Clobetasol Propionate-d5
CAS#2280940-18-1

Theoretical Analysis

MedKoo Cat#: 463967

Name: Clobetasol Propionate-d5

CAS#: 2280940-18-1

Chemical Formula: C25H27D5ClFO5

Exact Mass: 471.2236

Molecular Weight: 472.00

Elemental Analysis: C, 63.62; H, 7.90; Cl, 7.51; F, 4.03; O, 16.95

Price and Availability

Size Price Availability Quantity
1mg USD 550.00 2 Weeks
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Synonym
Clobetasol Propionate-d5; Clobetasol Propionate d5; CCI-4725-d5; CCI4725-d5; CCI 4725-d5; CGP 9555-d5; CGP9555-d5; CGP-9555-d5; Clobetasol 17-propionate-d5; Clobetasol 17 propionate-d5;
IUPAC/Chemical Name
(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propanoate-d5
InChi Key
CBGUOGMQLZIXBE-BFHSNLKKSA-N
InChi Code
InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1/i1D3,5D2
SMILES Code
O=C1C=C[C@]2(C(CC[C@@]3([C@@]2([C@H](C[C@]4([C@]3(C[C@@H]([C@]4(OC(C([2H])(C([2H])([2H])[2H])[2H])=O)C(CCl)=O)C)[H])C)O)F)[H])=C1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 472.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yuan P, Qiu X, Ye L, Hou F, Liang Y, Jiang H, Zhang Y, Xu Y, Sun Y, Deng X, Xu H, Jiang L. Efficacy of Topical Administration for Oral Lichen Planus: A Network Meta-Analysis. Oral Dis. 2021 Feb 2. doi: 10.1111/odi.13790. Epub ahead of print. PMID: 33529456. 2: Chudal D, Paudel V. Misuse of Topical Corticosteroids in Dermatological Disorders in Tribhuvan University Teaching Hospital. J Nepal Health Res Counc. 2021 Jan 21;18(4):729-733. doi: 10.33314/jnhrc.v18i4.2832. PMID: 33510519. 3: Zhong Z, McCafferty S, Opsomer L, Wang H, Huysmans H, De Temmerman J, Lienenklaus S, Portela Catani JP, Combes F, Sanders NN. Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs. Mol Ther. 2021 Jan 21:S1525-0016(21)00023-X. doi: 10.1016/j.ymthe.2021.01.023. Epub ahead of print. PMID: 33484964. 4: Lovato P, Jiang L, Hebsgaard J, Ewald DA, Norsgaard H. Calcipotriol/Betamethasone Dipropionate Foam Inhibits Th17 Cytokine Secretion and Improves Epidermal Barrier Markers in a Human Th17 Skin Inflammation Model. Dermatol Ther (Heidelb). 2021 Feb;11(1):265-274. doi: 10.1007/s13555-020-00482-9. Epub 2021 Jan 17. PMID: 33458806. 5: Mumtaz H, Anis S, Akhtar A, Rubab M, Zafar A, Niazi N, Bahadur H, Talpur AS, Shafiq MA, Fatima T. Efficacy of Tacrolimus Versus Clobetasol in the Treatment of Vitiligo. Cureus. 2020 Dec 8;12(12):e11985. doi: 10.7759/cureus.11985. PMID: 33437542; PMCID: PMC7793363. 6: Storrer CLM, Rigo Junior D, Teixeira L, Costa EE, Endres BR, Dos Santos DVF, Sebastiani AM. Benign Mucosal Membrane Pemphigoid as a Differential Diagnosis of Necrotizing Periodontal Disease. Case Rep Dent. 2020 Dec 22;2020:8885158. doi: 10.1155/2020/8885158. PMID: 33425400; PMCID: PMC7772047. 7: Sethi M, Garg V, Lee JB, Yang S. PD1 inhibitor induced inverse lichenoid eruption: a case series. Dermatol Online J. 2020 Dec 15;26(12):13030/qt66b8298z. PMID: 33423421. 8: Nomiyama T, Katoh N. Clobetasol propionate 0.05% under occlusion for alopecia areata: Clinical effect and influence on intraocular pressure. Australas J Dermatol. 2021 Jan 3. doi: 10.1111/ajd.13479. Epub ahead of print. PMID: 33393075. 9: Santonocito S, Polizzi A, De Pasquale R, Ronsivalle V, Lo Giudice A, Isola G. Analysis of the Efficacy of Two Treatment Protocols for Patients with Symptomatic Oral Lichen Planus: A Randomized Clinical Trial. Int J Environ Res Public Health. 2020 Dec 23;18(1):56. doi: 10.3390/ijerph18010056. PMID: 33374791; PMCID: PMC7794703. 10: Kumar S, Prasad M, Rao R. Topical delivery of clobetasol propionate loaded nanosponge hydrogel for effective treatment of psoriasis: Formulation, physicochemical characterization, antipsoriatic potential and biochemical estimation. Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111605. doi: 10.1016/j.msec.2020.111605. Epub 2020 Oct 9. PMID: 33321649. 11: Verma SB, Madke B. Topical corticosteroid induced ulcerated striae. An Bras Dermatol. 2021 Jan-Feb;96(1):94-96. doi: 10.1016/j.abd.2020.07.003. Epub 2020 Nov 18. PMID: 33288366; PMCID: PMC7838120. 12: Dulski A, Varamo V. Palmoplantar Pustulosis: A Case Report. Clin Pract Cases Emerg Med. 2020 Nov;4(4):664-667. doi: 10.5811/cpcem.2020.7.48476. PMID: 33217303; PMCID: PMC7676767. 13: Alkhatieb M, Mortada H. Truncal necrobiosis lipoidica diabeticorum: A first case report. Int J Surg Case Rep. 2020;77:311-313. doi: 10.1016/j.ijscr.2020.11.009. Epub 2020 Nov 8. PMID: 33197774; PMCID: PMC7677668. 14: Ganjei Z, Bahmani K. A case report of hydroxychloroquine-induced auditory and visual hallucination. Int J Clin Pharmacol Ther. 2020 Nov 16. doi: 10.5414/CP203789. Epub ahead of print. PMID: 33191905. 15: Mofarrah R, Mofarrah R, Jahani Amiri K, Ghasemi M. Co-localization of alopecia areata and lichen planopilaris in a patient receiving immunosuppressants: A rare case. J Cosmet Dermatol. 2020 Jul 24. doi: 10.1111/jocd.13600. Epub ahead of print. PMID: 33167077. 16: Cantwell HM, Wieland CN, Proffer SL, Imhof RL, Torgerson RR, Tolkachjov SN. Lichen planopilaris in men: a retrospective clinicopathologic study of 19 patients. Int J Dermatol. 2020 Oct 31. doi: 10.1111/ijd.15285. Epub ahead of print. PMID: 33128471. 17: Yadav K, Singh D, Singh MR, Pradhan M. Multifaceted targeting of cationic liposomes via co-delivery of anti-IL-17 siRNA and corticosteroid for topical treatment of psoriasis. Med Hypotheses. 2020 Dec;145:110322. doi: 10.1016/j.mehy.2020.110322. Epub 2020 Oct 2. PMID: 33086162. 18: Su X, Yuan H, Bai Y, Chen J, Sui M, Zhang X, Liang Y, Feng W, Dou Z, Zhu H. Clobetasol Attenuates White Matter Injury by Promoting Oligodendrocyte Precursor Cell Differentiation. Pediatr Neurosurg. 2020;55(4):188-196. doi: 10.1159/000509521. Epub 2020 Oct 9. PMID: 33040067. 19: Chirayath D, Shaheena S. Iatrogenic hypercortisolism in a Persian kitten after topical application of a skin lotion containing clobetasol. Vet Dermatol. 2020 Dec;31(6):486-488. doi: 10.1111/vde.12903. Epub 2020 Oct 7. PMID: 33029837. 20: Ferri EP, Cunha KRL, Abboud CS, de Barros Gallo C, de Sousa Sobral S, de Fatima Teixeira da Silva D, Horliana ACRT, Franco AL, Rodrigues MFSD. Photobiomodulation is effective in oral lichen planus: A randomized, controlled, double-blind study. Oral Dis. 2020 Oct 4. doi: 10.1111/odi.13662. Epub ahead of print. PMID: 33012017.