JXL069 is a potent and selective mitochondrial pyruvate carrier (MPC) inhibitor that disrupts pyruvate import into mitochondria, thereby modulating cellular metabolism. In biochemical assays, JXL069 demonstrated submicromolar inhibitory activity against MPC, with an IC₅₀ value of approximately 0.53 µM in MPC1/2-mediated pyruvate transport assays. Cellular studies showed that JXL069 effectively reduces mitochondrial oxygen consumption and pyruvate-driven respiration in cancer cell lines, with an EC₅₀ around 1–2 µM depending on the cell type. Functionally, treatment with JXL069 induces a metabolic shift toward glycolysis and impairs proliferation in MPC-dependent tumor cells, supporting its potential as a chemical probe for studying mitochondrial metabolism and as a lead compound for targeting metabolic vulnerabilities in cancer.
MedKoo Cat#: 463966
Name: JXL069
CAS#: 2260696-63-5
Chemical Formula: C20H11F6N3O2
Exact Mass: 439.0755
Molecular Weight: 439.32
Elemental Analysis: C, 54.68; H, 2.52; F, 25.95; N, 9.57; O, 7.28
The following data is based on the product molecular weight 439.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
