Synonym
Chlorproguanil; Chlorproguanilum; Clorpreguanile
IUPAC/Chemical Name
1-(3,4-Dichlorophenyl)-5-isopropylbiguanide
InChi Key
ISZNZKHCRKXXAU-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H15Cl2N5/c1-6(2)16-10(14)18-11(15)17-7-3-4-8(12)9(13)5-7/h3-6H,1-2H3,(H5,14,15,16,17,18)
SMILES Code
N=C(NC(NC(C)C)=N)NC1=CC=C(Cl)C(Cl)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
288.18
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bukirwa H, Garner P, Critchley J. Chlorproguanil-dapsone for treating uncomplicated malaria. Cochrane Database Syst Rev. 2004 Oct 18;2004(4):CD004387. doi: 10.1002/14651858.CD004387.pub2. PMID: 15495106; PMCID: PMC6532720.
2: Noor N, Rattani A. Chlorproguanil-dapsone for malaria. Lancet. 2004 Nov 13-19;364(9447):1753-4. doi: 10.1016/S0140-6736(04)17390-X. PMID: 15541442.
3: Mutabingwa T, Nzila A, Mberu E, Nduati E, Winstanley P, Hills E, Watkins W. Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania. Lancet. 2001 Oct 13;358(9289):1218-23. doi: 10.1016/S0140-6736(01)06344-9. Erratum in: Lancet 2001 Nov 3;358(9292):1556. PMID: 11675058.
4: Sulo J, Chimpeni P, Hatcher J, Kublin JG, Plowe CV, Molyneux ME, Marsh K, Taylor TE, Watkins WM, Winstanley PA. Chlorproguanil-dapsone versus sulfadoxine- pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial. Lancet. 2002 Oct 12;360(9340):1136-43. doi: 10.1016/s0140-6736(02)11198-6. PMID: 12387962.
5: Looareesuwan S, Imwong M, Wilairatana P. Chlorproguanil-dapsone for malaria in Africa. Lancet. 2004 Jun 5;363(9424):1838-9. doi: 10.1016/S0140-6736(04)16390-3. PMID: 15183616.
6: Standing JF, Wong IC. Chlorproguanil-dapsone for malaria. Lancet. 2004 Nov 13-19;364(9447):1752-3; author reply 1753. doi: 10.1016/S0140-6736(04)17388-1. PMID: 15541439.
7: Amukoye E, Winstanley PA, Watkins WM, Snow RW, Hatcher J, Mosobo M, Ngumbao E, Lowe B, Ton M, Minyiri G, Marsh K. Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria. Antimicrob Agents Chemother. 1997 Oct;41(10):2261-4. doi: 10.1128/AAC.41.10.2261. PMID: 9333058; PMCID: PMC164103.
8: Elewa H, Wilby KJ. A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications. Eur J Drug Metab Pharmacokinet. 2017 Oct;42(5):745-756. doi: 10.1007/s13318-016-0399-1. PMID: 28070879.
9: Winstanley P, Watkins W, Muhia D, Szwandt S, Amukoye E, Marsh K. Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic range. Trans R Soc Trop Med Hyg. 1997 May-Jun;91(3):322-7. doi: 10.1016/s0035-9203(97)90093-6. PMID: 9231209.
10: Winstanley P. Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria. Trop Med Int Health. 2001 Nov;6(11):952-4. doi: 10.1046/j.1365-3156.2001.00751.x. PMID: 11703851.
