MedKoo Cat#: 413168 | Name: Chloroprednisone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chloroprednisone is a topical glucocorticoid first reported in 1960. It is a chlorinated derivative of prednisone. The acetate ester prodrug, chloroprednisone 21-acetate, was sold under the brand name Topilan as an anti-inflammatory agent.

Chemical Structure

Chloroprednisone
Chloroprednisone
CAS#52080-57-6

Theoretical Analysis

MedKoo Cat#: 413168

Name: Chloroprednisone

CAS#: 52080-57-6

Chemical Formula: C21H25ClO5

Exact Mass: 392.1391

Molecular Weight: 392.88

Elemental Analysis: C, 64.20; H, 6.41; Cl, 9.02; O, 20.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Chloroprednisone; Chlorprednisonum; EINECS 257-644-2
IUPAC/Chemical Name
6alpha-Chloro-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
InChi Key
NPSLCOWKFFNQKK-ZPSUVKRCSA-N
InChi Code
InChI=1S/C21H25ClO5/c1-19-5-3-11(24)7-14(19)15(22)8-12-13-4-6-21(27,17(26)10-23)20(13,2)9-16(25)18(12)19/h3,5,7,12-13,15,18,23,27H,4,6,8-10H2,1-2H3/t12-,13-,15-,18+,19-,20-,21-/m0/s1
SMILES Code
C[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])C[C@H](Cl)C4=CC(C=C[C@]4(C)[C@@]3([H])C2=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 392.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: SCHWARZ K, KONZELMANN M, WRAN R. [On the local effects of 6alpha- chloroprednisone acetate]. Praxis. 1961 Sep 28;50:1015-8. German. PMID: 13909775.