MedKoo Cat#: 463951 | Name: Alfatradiol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alfatradiol, also known as 17α-estradiol and sold under the brand names Avicis, Avixis, Ell-Cranell Alpha, and Pantostin, is a weak estrogen and 5α-reductase inhibitor medication which is used topically in the treatment of pattern hair loss in men and women. It is a stereoisomer of the endogenous steroid hormone and estrogen 17β-estradiol.

Chemical Structure

Alfatradiol
CAS#57-91-0

Theoretical Analysis

MedKoo Cat#: 463951

Name: Alfatradiol

CAS#: 57-91-0

Chemical Formula: C18H24O2

Exact Mass: 272.1776

Molecular Weight: 272.39

Elemental Analysis: C, 79.37; H, 8.88; O, 11.75

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 2 Weeks
500mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Alfatradiol; NSC 20293; NSC-20293; NSC20293; 17α-estradiol; 17α estradiol; Avicis; Avixis; Ell-Cranell Alpha; Pantostin; α-Estradiol;
IUPAC/Chemical Name
(8R,9S,13S,14S,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
InChi Key
VOXZDWNPVJITMN-SFFUCWETSA-N
InChi Code
InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
SMILES Code
O[C@@H]1CC[C@@]2([H])[C@]([C@]3([H])CC[C@@]21C)([H])CCC4=C3C=CC(O)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 272.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Blume-Peytavi U, Kunte C, Krisp A, Garcia Bartels N, Ellwanger U, Hoffmann R. Comparison of the efficacy and safety of topical minoxidil and topical alfatradiol in the treatment of androgenetic alopecia in women. J Dtsch Dermatol Ges. 2007 May;5(5):391-5. English, German. doi: 10.1111/j.1610-0387.2007.06295.x. PMID: 17451383. 2: Lee JW, Yu DA, Cho S, Youn SW, Kwon O. Hair loss after drug reaction with eosinophilia and systemic symptoms (DRESS): A multicentric retrospective case series. J Dermatol. 2023 Jun;50(6):814-819. doi: 10.1111/1346-8138.16715. Epub 2023 Jan 17. PMID: 36651019.