Synonym
Clopirac; CP172 AP; CP-172 AP; CP 172 AP; BRL13856; BRL-13856; BRL 13856
IUPAC/Chemical Name
1-p-Chlorophenyl-2,5-dimethyl-3-pyrroleacetic acid
InChi Key
SJCRQMUYEQHNTC-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H14ClNO2/c1-9-7-11(8-14(17)18)10(2)16(9)13-5-3-12(15)4-6-13/h3-7H,8H2,1-2H3,(H,17,18)
SMILES Code
O=C(O)CC1=C(C)N(C2=CC=C(Cl)C=C2)C(C)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
263.72
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. [Clopirac effectiveness in traumatology and non articular rheumatisms (author's transl)].
Diverse P.
J Belge Rhumatol Med Phys. 1975;30 Spec no:152-9.
PMID: 1084346 French. No abstract available.
2. [Clopirac in traumatology (author's transl)].
Dewijze M, Dony J, Stehman M.
J Belge Rhumatol Med Phys. 1975;30 Spec no:239-46.
PMID: 776997 Clinical Trial. French. No abstract available.
3. [Clinical study of clopirac in traumatology (author's transl)].
Mihail A.
J Belge Rhumatol Med Phys. 1975;30 Spec no:251-3.
PMID: 776998 Clinical Trial. French. No abstract available.
4. [Clopirac in the treatment of posttraumatic inflammation (author's transl)].
Daenens L.
J Belge Rhumatol Med Phys. 1975;30 Spec no:247-50.
PMID: 1228197 Dutch. No abstract available.
5. [Double-blind study comparing effectiveness of clopirac and indomethacine in osteoarthritis of the hip and the knee (author's transl)].
Anciaux H, Appelboom T, Biltris R, Chantraine A, Coutellier P, Danaux R, Dessers E, Dumont M, Faure J, François P, Gilles V, Moens C, Postelmans J, Robyns R, Siquet L, Vandeputte L, Van Heuken Y, Van Rossum P, Verheugen P.
J Belge Rhumatol Med Phys. 1975;30 Spec no:189-99.
PMID: 776990 Clinical Trial. French. No abstract available.
6. [Studies of the therapeutic effectiveness of clopirac in non articular rheumatism (author's transl)].
Wauters M.
J Belge Rhumatol Med Phys. 1975;30 Spec no:144-51.
PMID: 132448 French. No abstract available.
7. [Clinical study with 1-parachlorophenyl-2,5-dimethylpyrroleacetic acid--clopirac (author's transl)].
Wauters M.
J Belge Rhumatol Med Phys. 1975;30 Spec no:169-73.
PMID: 776988 Clinical Trial. French. No abstract available.
8. [Clinical study of clopirac in osteoarthritis and non articular rheumatisms (author's transl)].
Weissenbach R.
J Belge Rhumatol Med Phys. 1975;30 Spec no:174-81.
PMID: 776989 Clinical Trial. French. No abstract available.
9. The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs.
Boyle E, Freeman PC, Goudie AC, Mangan FR, Thomson M.
J Pharm Pharmacol. 1976 Dec;28(12):865-8. doi: 10.1111/j.2042-7158.1976.tb04081.x.
PMID: 12259
The ability of several non-steroidal acidic anti-inflammatory drugs to cause ulceration when given as copper complexes has been examined. The damage caused by clopirac, niflumic acid and aspirin was virtually abolished when they were given as copper complexes whereas the d …
10. [Survey of the clinical studies of clopirac in traumatology (author's transl)].
Stehman M.
