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MedKoo Cat#: 413143 | Name: Clopenthixol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Chemical Structure

Clopenthixol
Clopenthixol
CAS#982-24-1 (free base)

Theoretical Analysis

MedKoo Cat#: 413143

Name: Clopenthixol

CAS#: 982-24-1 (free base)

Chemical Formula: C22H25ClN2OS

Exact Mass: 400.1376

Molecular Weight: 400.97

Elemental Analysis: C, 65.90; H, 6.28; Cl, 8.84; N, 6.99; O, 3.99; S, 8.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Clopenthixol; Sordinol; Clopenthixolum
IUPAC/Chemical Name
1-Piperazineethanol, 4-(3-(2-chloro-9H-thioxanthen-9-ylidene)propyl)-
InChi Key
WFPIAZLQTJBIFN-BLLMUTORSA-N
InChi Code
InChI=1S/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2/b18-5+
SMILES Code
OCCN1CCN(CC/C=C2C3=C(SC4=C/2C=CC=C4)C=CC(Cl)=C3)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 400.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. 2. The pharmacokinetics of long-acting antipsychotic medications. Spanarello S, La Ferla T. 3. Serum concentrations of cis(Z)- and trans(E)-clopenthixol after administration of cis(Z)-clopenthixol and clopenthixol to human volunteers. 4. Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation. 5. Pharmacokinetic studies on clopenthixol decanoate; a comparison with clopenthixol in dogs and rats. 6. Zuclopenthixol dihydrochloride for schizophrenia. 7. Clopenthixol decanoate in schizophrenia. 8. Effect of trans(E)-clopenthixol on Plasmodium berghei in vivo. 9. Serum levels of the isomers of clopenthixol in patients given cis(Z)-clopenthixol or cis(Z)/trans(E)-clopenthixol. 10. A specific method for assay of drug levels in serum of patients treated with clopenthixol decanoate injections.