Synonym
Clofluperol; Seperidol; Clofluperolum
IUPAC/Chemical Name
4-(4-(4-Chloro-3-(trifluoromethyl)phenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone
InChi Key
LZFSKNPPWIFMFL-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H22ClF4NO2/c23-19-8-5-16(14-18(19)22(25,26)27)21(30)9-12-28(13-10-21)11-1-2-20(29)15-3-6-17(24)7-4-15/h3-8,14,30H,1-2,9-13H2
SMILES Code
O=C(C1=CC=C(F)C=C1)CCCN2CCC(O)(C3=CC=C(Cl)C(C(F)(F)F)=C3)CC2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
443.87
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chiou GC. Treatment of ocular hypertension and glaucoma with dopamine antagonists. Ophthalmic Res. 1984;16(3):129-34. doi: 10.1159/000265307. PMID: 6147806.
2: Aimoto T, Masuda C, Murata T. [Biopharmaceutical studies on neuroleptic butyrophenones. IV. Sex differences in the disposition of clofluperol in the rat (author's transl)]. Yakugaku Zasshi. 1979 Aug;99(8):851-4. Japanese. doi: 10.1248/yakushi1947.99.8_851. PMID: 541776.
3: Janssen PA, Allewijn FT. The distribution of the butyrophenones haloperidol, trifluperidol, moperone, and clofluperol in rats, and its relationship with their neuroleptic activity. Arzneimittelforschung. 1969 Feb;19(2):199-208. PMID: 5818759.
4: Bobon J, Pinchard A, Goffioul F, Devroye A, Bobon DP, Korn M. Neuroleptiques à longue durée d'action. I. Etude pilote du clofluperol (R9298) [Long-acting neuroleptics. I. Pilot study of clofluperol (R9298)]. Acta Neurol Psychiatr Belg. 1968 Feb;68(2):128-36. French. PMID: 4972601.
5: Boehme RE, Ciaranello RD. Dopamine receptor binding in inbred mice: strain differences in mesolimbic and nigrostriatal dopamine binding sites. Proc Natl Acad Sci U S A. 1981 May;78(5):3255-9. doi: 10.1073/pnas.78.5.3255. PMID: 6166945; PMCID: PMC319540.
6: Aimoto T, Kaida M, Sato M, Sato M, Kimura R, Murata T. Effects of neuroleptic butyrophenones on pituitary-adrenal activity in rats. J Pharmacobiodyn. 1980 Jan;3(1):46-52. doi: 10.1248/bpb1978.3.46. PMID: 6110713.
7: Aimoto T, Kaida M, Numazaki K, Masuda Y, Murata T. Development of tolerance to the stimulatory effect of neuroleptic butyrophenones on pituitary-adrenal activity in rats. J Pharmacobiodyn. 1981 Nov;4(11):827-32. doi: 10.1248/bpb1978.4.827. PMID: 6120222.
8: Aimoto T, Unno K, Hayashi H, Murata T. [Biopharmaceutical studies on neuroleptic butyrophenones. V. Effects of chronic treatment on adrenal and hepatic drug-metabolizing enzyme system in rats (author's transl)]. Yakugaku Zasshi. 1979 Oct;99(10):1014-20. Japanese. doi: 10.1248/yakushi1947.99.10_1014. PMID: 544743.
