FB23 inhibitor | CAS# 2243736-35-6 | FTO inhibitor

MedKoo Cat#: 555906 | Name: FB23 inhibitor

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FB23 is a potent and selective inhibitor of N6-methyladenosine (m6A) demethylase FTO (fat mass and obesity associated protein). It moderately inhibits proliferation of NB4 and MONOMAC6 cells. FB23 demonstrates its potent inhibitory impact in AML models.

Chemical Structure

FB23 inhibitor

CAS# 2243736-35-6

Theoretical Analysis

MedKoo Cat#: 555906

Name: FB23 inhibitor

CAS#: 2243736-35-6

Chemical Formula: C18H14Cl2N2O3

Exact Mass: 376.0381

Molecular Weight: 377.22

Elemental Analysis: C, 57.31; H, 3.74; Cl, 18.80; N, 7.43; O, 12.72

Price and Availability

Size	Price	Availability
100mg	USD 1,450.00	2 Weeks
200mg	USD 2,150.00	2 Weeks
500mg	USD 2,950.00	2 Weeks
1g	USD 3,950.00	2 Weeks
2g	USD 6,970.00	2 Weeks

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Related CAS #

No Data

Synonym

FB23 inhibitor; FB-23; FB 23;

IUPAC/Chemical Name

2-[[2,6-Dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]benzoic acid

InChi Key

VUXZATVQMFSUCM-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H14Cl2N2O3/c1-9-16(10(2)25-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(23)24/h3-8,21H,1-2H3,(H,23,24)

SMILES Code

O=C(O)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 377.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhao T, Wang J, Wu Y, Han L, Chen J, Wei Y, Shen L, Long C, Wu S, Wei G. Increased m6A modification of RNA methylation related to the inhibition of demethylase FTO contributes to MEHP-induced Leydig cell injury☆. Environ Pollut. 2021 Jan 1;268(Pt A):115627. doi: 10.1016/j.envpol.2020.115627. Epub 2020 Sep 24. PMID: 33010548. 2: Yu J, Zhang Y, Ma H, Zeng R, Liu R, Wang P, Jin X, Zhao Y. Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury. Mol Brain. 2020 Jan 28;13(1):11. doi: 10.1186/s13041-020-0554-0. PMID: 31992337; PMCID: PMC6986156. 3: Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, Zhu Z, Lian F, Wei J, Deng Q, Wang Y, Wunderlich M, Gao Z, Pan G, Zhong D, Zhou H, Zhang N, Gan J, Jiang H, Mulloy JC, Qian Z, Chen J, Yang CG. Small- Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35(4):677-691.e10. doi: 10.1016/j.ccell.2019.03.006. PMID: 30991027; PMCID: PMC6812656. 4: Van Der Werf I, Jamieson C. The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells. Cancer Cell. 2019 Apr 15;35(4):540-541. doi: 10.1016/j.ccell.2019.03.011. PMID: 30991023. 5: Liu J, Meng Y, Lv F, Chen J, Ma Y, Wang Y, Chen B, Zhang L, Zhou Z. Photosynthetic characteristics of the subtending leaf of cotton boll at different fruiting branch nodes and their relationships with lint yield and fiber quality. Front Plant Sci. 2015 Sep 17;6:747. doi: 10.3389/fpls.2015.00747. PMID: 26442060; PMCID: PMC4584985. 6: Kuai J, Liu Z, Wang Y, Meng Y, Chen B, Zhao W, Zhou Z, Oosterhuis DM. Waterlogging during flowering and boll forming stages affects sucrose metabolism in the leaves subtending the cotton boll and its relationship with boll weight. Plant Sci. 2014 Jun;223:79-98. doi: 10.1016/j.plantsci.2014.03.010. Epub 2014 Mar 15. PMID: 24767118. 7: Okitsu SL, Boato F, Mueller MS, Li DB, Vogel D, Westerfeld N, Zurbriggen R, Robinson JA, Pluschke G. Antibodies elicited by a virosomally formulated Plasmodium falciparum serine repeat antigen-5 derived peptide detect the processed 47 kDa fragment both in sporozoites and merozoites. Peptides. 2007 Oct;28(10):2051-60. doi: 10.1016/j.peptides.2007.08.007. Epub 2007 Aug 17. PMID: 17875342. 8: Zhang B, Wang Q, Wang K, Pan X, Liu F, Guo T, Cobb GP, Anderson TA. Identification of cotton microRNAs and their targets. Gene. 2007 Aug 1;397(1-2):26-37. doi: 10.1016/j.gene.2007.03.020. Epub 2007 Apr 20. PMID: 17574351