OM99-2 | CAS# 314266-76-7 | Biochemical

MedKoo Cat#: 575907 | Name: OM99-2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OM99-2 is an eight-residue Memapsin 2 and Beta-Secretase inhibitor.

Chemical Structure

OM99-2

CAS#314266-76-7

Theoretical Analysis

MedKoo Cat#: 575907

Name: OM99-2

CAS#: 314266-76-7

Chemical Formula: C41H64N8O14

Exact Mass: 892.4542

Molecular Weight: 893.00

Elemental Analysis: C, 55.15; H, 7.22; N, 12.55; O, 25.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

OM99-2; OM 99-2; OM-99-2

IUPAC/Chemical Name

(2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-17-(2-amino-2-oxoethyl)-2-benzyl-5-(2-carboxyethyl)-13-hydroxy-14-isobutyl-20-isopropyl-8,11-dimethyl-4,7,10,16,19,22-hexaoxo-3,6,9,15,18,21-hexaazahexacosanedioic acid

InChi Key

NIOCOJFPGCXNKL-ZKZXETMPSA-N

InChi Code

1S/C41H64N8O14/c1-20(2)16-27(46-39(60)28(19-31(43)51)47-40(61)34(21(3)4)49-37(58)25(42)12-14-32(52)53)30(50)17-22(5)35(56)44-23(6)36(57)45-26(13-15-33(54)55)38(59)48-29(41(62)63)18-24-10-8-7-9-11-24/h7-11,20-23,25-30,34,50H,12-19,42H2,1-6H3,(H2,43,51)(H,44,56)(H,45,57)(H,46,60)(H,47,61)(H,48,59)(H,49,58)(H,52,53)(H,54,55)(H,62,63)/t22-,23+,25+,26+,27+,28+,29+,30+,34+/m1/s1

SMILES Code

CC(C)C[C@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 893.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Hu B, Xiong B, Qiu BY, Li X, Yu HP, Xiao K, Wang X, Li J, Shen JK. Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to beta-secretase. Acta Pharmacol Sin. 2006 Dec;27(12):1586-93. doi: 10.1111/j.1745-7254.2006.00432.x. PMID: 17112413. 2. Hong L, Turner RT 3rd, Koelsch G, Ghosh AK, Tang J. Memapsin 2 (beta-secretase) as a therapeutic target. Biochem Soc Trans. 2002 Aug;30(4):530-4. doi: 10.1042/bst0300530. PMID: 12196130. 3. Turner RT 3rd, Koelsch G, Hong L, Castanheira P, Ermolieff J, Ghosh AK, Tang J. Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design. Biochemistry. 2001 Aug 28;40(34):10001-6. doi: 10.1021/bi015546s. Erratum in: Biochemistry 2001 Oct 9;40(40):12230. Castenheira, P [corrected to Castanheira, P]; Ghosh, A [corrected to Ghosh, AK]. PMID: 11513577.