Synonym
CLR-1502; CLR 1502; CLR1502; GLOW2
IUPAC/Chemical Name
18-((E)-6'-((E)-2-(1,3,3-trimethyl-3H-indol-1-ium-2-yl)vinyl)-2'-(2-((E)-1,3,3-trimethylindolin-2-ylidene)ethylidene)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-4-yl)octadecyl (2-(trimethylammonio)ethyl) phosphate chloride
InChi Key
ABHSKOMCZVVTMW-UHFFFAOYSA-M
InChi Code
InChI=1S/C61H89N3O4P.ClH/c1-60(2)53-34-25-27-36-55(53)62(5)57(60)44-42-50-32-30-33-51(43-45-58-61(3,4)54-35-26-28-37-56(54)63(58)6)59(50)52-40-38-49(39-41-52)31-24-22-20-18-16-14-12-10-11-13-15-17-19-21-23-29-47-67-69(65,66)68-48-46-64(7,8)9;/h25-28,34-45H,10-24,29-33,46-48H2,1-9H3;1H/q+1;/p-1
SMILES Code
[Cl-].CN1\C(=C\C=C\2/CCCC(=C2c3ccc(CCCCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C)cc3)\C=C\C4=[N+](C)c5ccccc5C4(C)C)\C(C)(C)c6ccccc16
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
994.82
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Swanson KI, Clark PA, Zhang RR, Kandela IK, Farhoud M, Weichert JP, Kuo JS. Fluorescent cancer-selective alkylphosphocholine analogs for intraoperative glioma detection. Neurosurgery. 2015 Feb;76(2):115-23; discussion 123-4. doi: 10.1227/NEU.0000000000000622. PMID: 25549194; PMCID: PMC4343207.
2. Korb ML, Warram JM, Grudzinski J, Weichert J, Jeffery J, Rosenthal EL. Breast cancer imaging using the near-infrared fluorescent agent, CLR1502. Mol Imaging. 2014;13. doi: 10.2310/7290.2014.00040. PMID: 25743270.
3. Deming DA, Maher ME, Leystra AA, Grudzinski JP, Clipson L, Albrecht DM, Washington MK, Matkowskyj KA, Hall LT, Lubner SJ, Weichert JP, Halberg RB. Phospholipid ether analogs for the detection of colorectal tumors. PLoS One. 2014 Oct 6;9(10):e109668. doi: 10.1371/journal.pone.0109668. PMID: 25286226; PMCID: PMC4186834.
4. Clark PA, Al-Ahmad AJ, Qian T, Zhang RR, Wilson HK, Weichert JP, Palecek SP, Kuo JS, Shusta EV. Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model. Mol Pharm. 2016 Sep 6;13(9):3341-9. doi: 10.1021/acs.molpharmaceut.6b00441. Epub 2016 Aug 4. PMID: 27421304; PMCID: PMC5014630.
