Synonym
Clobuzarit; ICI55,897; ICI-55,897; ICI 55,897
IUPAC/Chemical Name
2-((4'-Chloro-4-biphenylyl)methoxy)-2-methylpropionic acid
InChi Key
UGOFYAXVVVXMQT-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H17ClO3/c1-17(2,16(19)20)21-11-12-3-5-13(6-4-12)14-7-9-15(18)10-8-14/h3-10H,11H2,1-2H3,(H,19,20)
SMILES Code
CC(C)(OCC1=CC=C(C2=CC=C(Cl)C=C2)C=C1)C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
304.77
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Bloxham DP, Bradshaw D, Cashin CH, Dodge BB, Lewis EJ, Westmacott D, Self CR. Biologic properties of romazarit (Ro 31-3948), a potential disease-modifying antirheumatic drug. J Pharmacol Exp Ther. 1990 Mar;252(3):1331-40. PMID: 2156999.
6: Rainsford KD, Davies A, Mundy L, Ginsburg I. Comparative effects of azapropazone on cellular events at inflamed sites. Influence on joint pathology in arthritic rats, leucocyte superoxide and eicosanoid production, platelet aggregation, synthesis of cartilage proteoglycans, synovial production and actions of interleukin-1 in cartilage resorption correlated with drug uptake into cartilage in-vitro. J Pharm Pharmacol. 1989 May;41(5):322-30. doi: 10.1111/j.2042-7158.1989.tb06465.x. PMID: 2569519.
7: el Kebbaj MH, Cherkaoui Malki M, Latruffe N. Effect of peroxisomes proliferators and hypolipemic agents on mitochondrial inner membrane linked D-3-hydroxybutyrate dehydrogenase (BDH). Biochem Mol Biol Int. 1995 Jan;35(1):65-77. PMID: 7735141.
8: Wright V, Dixon JS, Bird HA. Therapeutic significance of laboratory results in rheumatic disease. Semin Arthritis Rheum. 1985 Nov;15(2 Suppl 1):8-13. doi: 10.1016/s0049-0172(85)80003-2. PMID: 2867602.
9: Sheppeard H, Pilsworth LM, Hazleman B, Dingle JT. Effects of antirheumatoid drugs on the production and action of porcine catabolin. Ann Rheum Dis. 1982 Oct;41(5):463-8. doi: 10.1136/ard.41.5.463. PMID: 6812508; PMCID: PMC1001023.
10: McConkey B, Amos RS, Billingham ME, Constable TJ, Crockson RA, Crockson AP, Forster PJ. Rheumatoid arthritis: effects of a new agent (ICI 55 897) on serum acute phase proteins and the erythrocyte sedimentation rate. Ann Rheum Dis. 1980 Feb;39(1):18-21. doi: 10.1136/ard.39.1.18. PMID: 6990881; PMCID: PMC1000463.
