Synonym
Climazolam; Climazolamum
IUPAC/Chemical Name
4H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-chlorophenyl)-1-methyl-
InChi Key
CHCISLOJADQUNQ-UHFFFAOYSA-N
InChi Code
CHCISLOJADQUNQ-UHFFFAOYSA-N
SMILES Code
CC1=NC=C2N1C3=CC=C(Cl)C=C3C(C4=CC=CC=C4Cl)=NC2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
342.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ganter M, Kanngiesser M. Auswirkung von Ketamin und dessen Kombinationen mit Xylazin und Climazolam auf Kreislauf und Atmung beim Schwein [Effect of ketamine and its combinations with xylazine and climazolam on the circulation and respiration in swine]. Zentralbl Veterinarmed A. 1991 Aug;38(7):501-9. German. PMID: 1950241.
2: West CD, Green CJ. The sedative effects of climazolam and climazolam with fentanyl-fluanisone in rats (Rattus norvegicus). Lab Anim. 1987 Apr;21(2):143-8. doi: 10.1177/002367728702100211. PMID: 3496489.
3: Axiak SM, Jäggin N, Wenger S, Doherr MG, Schatzmann U. Anaesthesia for castration of piglets: comparison between intranasal and intramuscular application of ketamine, climazolam and azaperone. Schweiz Arch Tierheilkd. 2007 Sep;149(9):395-402. doi: 10.1024/0036-7281.149.9.395. PMID: 17929705.
4: Bettschart-Wolfensberger R, Taylor PM, Sear JW, Bloomfield MR, Rentsch K, Dawling S. Physiologic effects of anesthesia induced and maintained by intravenous administration of a climazolam-ketamine combination in ponies premedicated with acepromazine and xylazine. Am J Vet Res. 1996 Oct;57(10):1472-7. PMID: 8896687.
5: Wettstein D, Moens Y, Jaeggin-Schmucker N, Böhm SH, Rothen HU, Mosing M, Kästner SB, Schatzmann U. Effects of an alveolar recruitment maneuver on cardiovascular and respiratory parameters during total intravenous anesthesia in ponies. Am J Vet Res. 2006 Jan;67(1):152-9. doi: 10.2460/ajvr.67.1.152. PMID: 16426225.
6: Becker M. Anesthesia in Göttingen miniature swine used for experimental surgery. Lab Anim Sci. 1986 Aug;36(4):417-9. PMID: 3773453.
7: Kaegi B. Injektionsanästhesie mit Xylazin, Ketamin und dem Benzodiazepinderivat Climazolam sowie Anwendung des Benzodiazepinantagonisten Ro 15-3505 [Anesthesia by injection of xylazine, ketamine and the benzodiazepine derivative climazolam and the use of the benzodiazepine antagonist Ro 15-3505]. Schweiz Arch Tierheilkd. 1990;132(5):251-7. German. PMID: 1975121.
8: Lee TC, Charles B. Measurement by HPLC of midazolam and its major metabolite, 1-hydroxymidazolam in plasma of very premature neonates. Biomed Chromatogr. 1996 Mar-Apr;10(2):65-8. doi: 10.1002/(SICI)1099-0801(199603)10:2<65::AID- BMC555>3.0.CO;2-Q. PMID: 8924728.
9: Schlosser S, Spanholtz T, Merz K, Dennler C, Banic A, Erni D, Plock JA. The choice of anesthesia influences oxidative energy metabolism and tissue survival in critically ischemic murine skin. J Surg Res. 2010 Aug;162(2):308-13. doi: 10.1016/j.jss.2009.03.007. Epub 2009 Apr 10. PMID: 19592025.
10: Van Miert AS, Koot M, Van Duin CT. Appetite-modulating drugs in dwarf goats, with special emphasis on benzodiazepine-induced hyperphagia and its antagonism by flumazenil and RO 15-3505. J Vet Pharmacol Ther. 1989 Jun;12(2):147-56. doi: 10.1111/j.1365-2885.1989.tb00656.x. PMID: 2501511.
