MedKoo Cat#: 575863 | Name: GET-73

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GET-73 is an mGluR5 negative allosteric modulator.

Chemical Structure

GET-73
GET-73
CAS#202402-01-5

Theoretical Analysis

MedKoo Cat#: 575863

Name: GET-73

CAS#: 202402-01-5

Chemical Formula: C13H16F3NO2

Exact Mass: 275.1133

Molecular Weight: 275.27

Elemental Analysis: C, 56.72; H, 5.86; F, 20.71; N, 5.09; O, 11.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GET-73; GET 73; GET73
IUPAC/Chemical Name
4-Methoxy-N-((4-(trifluoromethyl)phenyl)methyl)-butanamide
InChi Key
QLZOWJNFLXSDSH-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H16F3NO2/c1-19-8-2-3-12(18)17-9-10-4-6-11(7-5-10)13(14,15)16/h4-7H,2-3,8-9H2,1H3,(H,17,18)
SMILES Code
COCCCC(=O)NCc1ccc(cc1)C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 275.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Haass-Koffler CL, Goodyear K, Long VM, Tran HH, Loche A, Cacciaglia R, Swift RM, Leggio L. A Phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers. Eur J Pharm Sci. 2017 Nov 15;109:78-85. doi: 10.1016/j.ejps.2017.07.031. Epub 2017 Aug 1. PMID: 28778464; PMCID: PMC5776031. 2. Haass-Koffler CL, Goodyear K, Long VM, Tran HH, Loche A, Cacciaglia R, Swift RM, Leggio L. Dataset for Phase I randomized clinical trial for safety and tolerability of GET 73 in single and repeated ascending doses including preliminary pharmacokinetic parameters. Data Brief. 2017 Sep 17;15:407-413. doi: 10.1016/j.dib.2017.09.018. PMID: 29214202; PMCID: PMC5712048.