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MedKoo Cat#: 413071 | Name: Epomediol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Epomediol is a synthetic terpenoid with choleretic effects. It has been used in the symptomatic treatment of itching due to intrahepatic cholestasis of pregnancy.

Chemical Structure

Epomediol
Epomediol
CAS# 56084-15-2

Theoretical Analysis

MedKoo Cat#: 413071

Name: Epomediol

CAS#: 56084-15-2

Chemical Formula: C10H18O3

Exact Mass: 186.1256

Molecular Weight: 186.25

Elemental Analysis: C, 64.49; H, 9.74; O, 25.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Epomediol; Clesidren
IUPAC/Chemical Name
2-Oxabicyclo(2.2.2)octane-6,7-diol, 1,3,3-trimethyl-
InChi Key
JSNQSLSBBZFGBM-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H18O3/c1-9(2)6-4-7(11)10(3,13-9)8(12)5-6/h6-8,11-12H,4-5H2,1-3H3
SMILES Code
OC1CC2C(C)(C)OC1(C)C(O)C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 186.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cuevas MJ, Mauriz JL, Almar M, Collado PS, González-Gallego J. Effect of epomediol on ethinyloestradiol-induced changes in bile acid and cholesterol metabolism in rats. Clin Exp Pharmacol Physiol. 2001 Aug;28(8):637-42. doi: 10.1046/j.1440-1681.2001.03496.x. PMID: 11473529. 2: Barone M, Azzarone A, Angelini A, Zamparella M, Dell'Aquila P, Francavilla A. Effect of epomediol on taurocholate uptake in hepatocytes isolated from normal rats or rats with ethinyloestradiol-induced cholestasis. Pharmacol Toxicol. 1993 Apr-May;72(4-5):296-9. doi: 10.1111/j.1600-0773.1993.tb01653.x. PMID: 8372050. 3: Gonzalez MC, Iglesias J, Tiribelli C, Ribalta J, Reyes H, Hernandez I, Bianchi M, Andrighetti F, Molina C. Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy. J Hepatol. 1992 Sep;16(1-2):241-2. doi: 10.1016/s0168-8278(05)80122-9. PMID: 1484159. 4: González M, Iglesias J, Tiribelli C, Ribalta J, Reyes H, Hernández I, Bianchi M, Andrighetti F, Molina C. Efecto sintomático del epomediol en pacientes con colestasis gravídica [Symptomatic effect of epomediol in patients with cholestasis of pregnancy]. Rev Med Chil. 1992 May;120(5):545-51. Spanish. PMID: 1343068. 5: Capurso L, Kock M, Ferrario F, Del Sette F, Gramolini C, Castiglioni CL. Activity of epomediol in the treatment of hepatopathies: a double-blind multi- centre study. J Int Med Res. 1987 May-Jun;15(3):134-47. doi: 10.1177/030006058701500303. PMID: 3301453. 6: Mauriz JL, Cuevas MJ, El-Mir MY, Almar M, Collado PS, Gonzalez-Gallego J. Enhancement of bile acid pool size, synthesis and secretion by epomediol in the rat. Dig Dis Sci. 2000 Jul;45(7):1431-8. doi: 10.1023/a:1005528725319. PMID: 10961725. 7: Zanninelli G, Tavanti A, Munoz ME, Ricci GL. Effect of the terpenic compound epomediol on biliary secretion and bile composition in the rat. J Hepatol. 1992 Jan;14(1):64-70. doi: 10.1016/0168-8278(92)90132-9. PMID: 1737917. 8: Miccio M, Orzes N, Lunazzi GC, Gazzin B, Corsi R, Tiribelli C. Reversal of ethinylestradiol-induced cholestasis by epomediol in rat. The role of liver plasma-membrane fluidity. Biochem Pharmacol. 1989 Oct 15;38(20):3559-63. doi: 10.1016/0006-2952(89)90128-7. PMID: 2554925. 9: Cuevas MJ, Almar M, González-Gallego J. Effects of epomediol on ethinyloestradiol-induced changes in glutathione homeostasis in the rat. Pharmacol Toxicol. 2002 Mar;90(3):121-6. doi: 10.1034/j.1600-0773.2002.900302.x. PMID: 12071332. 10: Reyes H, Simon FR. Intrahepatic cholestasis of pregnancy: an estrogen- related disease. Semin Liver Dis. 1993 Aug;13(3):289-301. doi: 10.1055/s-2007-1007357. PMID: 8235718.