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MedKoo Cat#: 463892 | Name: Erianin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Erianin is a benzoyl compound that has been found in D. chrysotoxum and has diverse biological activities. It inhibits the growth of H460 and H1299 lung cancer cells in a calcium/calmodulin-dependent manner, an effect that can be reversed by the ferroptosis inhibitor liproxstatin-1 or ferrostatin-1. Erianin reduces tumor volume in an H460 mouse xenograft model. It increases colon length and body weight, as well as decreases colonic inflammation and the number of colonic ulcers in a mouse model of ulcerative colitis induced by dextran sulfate. Erianin decreases retinal microglia accumulation, NF-kB signaling, and TNF-α mRNA expression, as well as attenuates blood-brain barrier breakdown in a mouse model of diabetic retinopathy induced by streptozotocin.

Chemical Structure

Erianin
Erianin
CAS#95041-90-0

Theoretical Analysis

MedKoo Cat#: 463892

Name: Erianin

CAS#: 95041-90-0

Chemical Formula: C18H22O5

Exact Mass: 318.1467

Molecular Weight: 318.37

Elemental Analysis: C, 67.91; H, 6.97; O, 25.13

Price and Availability

Size Price Availability Quantity
10mg USD 250.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 850.00 2 Weeks
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Related CAS #
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Synonym
Erianin; NSC 613744; NSC613744; NSC-613744;
IUPAC/Chemical Name
2-methoxy-5-(3,4,5-trimethoxyphenethyl)phenol
InChi Key
UXDFUVFNIAJEGM-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H22O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h7-11,19H,5-6H2,1-4H3
SMILES Code
OC1=CC(CCC2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.
In vitro activity:
To address the function of erianin on MDA-MB-231 and EFM-192A cells growth, MTT assay and DAPI staining were performed. MDA-MB-231 and EFM-192A cells’ proliferation was inhibited with erianin treatment in a dose-dependent way as shown in MTT analysis, with IC50 at 70.96 and 78.58 nM effective inhibition concentration at nanomolar level (Figure 1A). In addition, typical apoptotic morphology (chromatin condensation and fracture) was detected in MDA-MB-231 cells nucleus treated with 40, 80, or 160 nM erianin for 24 h in DAPI staining, indicating erianin may induce MDA-MB-231 cells apoptosis in a dose-dependent way (Figure 1B). Reference: Biosci Rep. 2021 Jun 25; 41(6): BSR20210093. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202065/
In vivo activity:
Second, in a mouse xenograft model of lewis lung cancer (LLC), oral administration of erianin (50, 35, and 10 mg kg-1 day-1 for 12 days) substantially inhibited nodule growth, reduced the fluorescence counts of lewis cells and the percentage vascularity of tumor tissues, increased the number of apoptotic tumor cells, the thymus indices, up-regulated the levels of interleukin (IL)-2 and tumor necrosis factor-α (TNF-α), decreased IL-10 levels and the spleen index, and enhanced immune function. Reference: Phytother Res. 2021 Jul 8. https://pubmed.ncbi.nlm.nih.gov/34236105/
Solvent mg/mL mM
Solubility
DMSO:PBS (pH 7.2) (1:8) 0.1 0.35
DMF 30.0 94.23
Ethanol 5.0 15.71
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 318.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Xu Y, Fang R, Shao J, Cai Z. Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway. Biosci Rep. 2021 Jun 25;41(6):BSR20210093. doi: 10.1042/BSR20210093. PMID: 34036307; PMCID: PMC8202065. 2. Xie H, Feng S, Farag MA, Sun P, Shao P. Synergistic cytotoxicity of erianin, a bisbenzyl in the dietetic Chinese herb Dendrobium against breast cancer cells. Food Chem Toxicol. 2021 Mar;149:111960. doi: 10.1016/j.fct.2020.111960. Epub 2020 Dec 30. PMID: 33385512. 3. Zhang HQ, Xie XF, Li GM, Chen JR, Li MT, Xu X, Xiong QY, Chen GR, Yin YP, Peng F, Chen Y, Peng C. Erianin inhibits human lung cancer cell growth via PI3K/Akt/mTOR pathway in vitro and in vivo. Phytother Res. 2021 Jul 8. doi: 10.1002/ptr.7154. Epub ahead of print. PMID: 34236105. 4. Yang A, Li MY, Zhang ZH, Wang JY, Xing Y, Ri M, Jin CH, Xu GH, Piao LX, Jin HL, Zuo HX, Ma J, Jin X. Erianin regulates programmed cell death ligand 1 expression and enhances cytotoxic T lymphocyte activity. J Ethnopharmacol. 2021 Jun 12;273:113598. doi: 10.1016/j.jep.2020.113598. Epub 2020 Nov 19. PMID: 33220359.
In vitro protocol:
1. Xu Y, Fang R, Shao J, Cai Z. Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway. Biosci Rep. 2021 Jun 25;41(6):BSR20210093. doi: 10.1042/BSR20210093. PMID: 34036307; PMCID: PMC8202065. 2. Xie H, Feng S, Farag MA, Sun P, Shao P. Synergistic cytotoxicity of erianin, a bisbenzyl in the dietetic Chinese herb Dendrobium against breast cancer cells. Food Chem Toxicol. 2021 Mar;149:111960. doi: 10.1016/j.fct.2020.111960. Epub 2020 Dec 30. PMID: 33385512.
In vivo protocol:
1. Zhang HQ, Xie XF, Li GM, Chen JR, Li MT, Xu X, Xiong QY, Chen GR, Yin YP, Peng F, Chen Y, Peng C. Erianin inhibits human lung cancer cell growth via PI3K/Akt/mTOR pathway in vitro and in vivo. Phytother Res. 2021 Jul 8. doi: 10.1002/ptr.7154. Epub ahead of print. PMID: 34236105. 2. Yang A, Li MY, Zhang ZH, Wang JY, Xing Y, Ri M, Jin CH, Xu GH, Piao LX, Jin HL, Zuo HX, Ma J, Jin X. Erianin regulates programmed cell death ligand 1 expression and enhances cytotoxic T lymphocyte activity. J Ethnopharmacol. 2021 Jun 12;273:113598. doi: 10.1016/j.jep.2020.113598. Epub 2020 Nov 19. PMID: 33220359.
1: Xie H, Feng S, Farag MA, Sun P, Shao P. Synergistic cytotoxicity of erianin, a bisbenzyl in the dietetic Chinese herb Dendrobium against breast cancer cells. Food Chem Toxicol. 2020 Dec 30;149:111960. doi: 10.1016/j.fct.2020.111960. Epub ahead of print. PMID: 33385512. 2: Ye LH, Zhang R, Cao J. Screening of β-secretase inhibitors from Dendrobii Caulis by covalently enzyme-immobilized magnetic beads coupled with ultra-high- performance liquid chromatography. J Pharm Biomed Anal. 2020 Dec 13:113845. doi: 10.1016/j.jpba.2020.113845. Epub ahead of print. PMID: 33371968. 3: Yang A, Li MY, Zhang ZH, Wang JY, Xing Y, Ri M, Jin CH, Xu GH, Piao LX, Jin HL, Zuo HX, Ma J, Jin X. Erianin regulates programmed cell death ligand 1 expression and enhances cytotoxic T lymphocyte activity. J Ethnopharmacol. 2020 Nov 18:113598. doi: 10.1016/j.jep.2020.113598. Epub ahead of print. PMID: 33220359. 4: Dong H, Wang M, Chang C, Sun M, Yang F, Li L, Feng M, Zhang L, Li Q, Zhu Y, Qiao Y, Xie T, Chen J. Erianin inhibits the oncogenic properties of hepatocellular carcinoma via inducing DNA damage and aberrant mitosis. Biochem Pharmacol. 2020 Dec;182:114266. doi: 10.1016/j.bcp.2020.114266. Epub 2020 Oct 6. PMID: 33035506. 5: Sun Y, Li G, Zhou Q, Shao D, Lv J, Zhou J. Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer. Drug Des Devel Ther. 2020 Aug 12;14:3301-3313. doi: 10.2147/DDDT.S259006. PMID: 32848368; PMCID: PMC7429191. 6: Yang L, Hu Y, Zhou G, Chen Q, Song Z. Erianin suppresses hepatocellular carcinoma cells through down-regulation of PI3K/AKT, p38 and ERK MAPK signaling pathways. Biosci Rep. 2020 Jul 31;40(7):BSR20193137. doi: 10.1042/BSR20193137. PMID: 32677672; PMCID: PMC7385585. 7: Chen P, Wu Q, Feng J, Yan L, Sun Y, Liu S, Xiang Y, Zhang M, Pan T, Chen X, Duan T, Zhai L, Zhai B, Wang W, Zhang R, Chen B, Han X, Li Y, Chen L, Liu Y, Huang X, Jin T, Zhang W, Luo H, Chen X, Li Y, Li Q, Li G, Zhang Q, Zhuo L, Yang Z, Tang H, Xie T, Ouyang X, Sui X. Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis. Signal Transduct Target Ther. 2020 May 8;5(1):51. doi: 10.1038/s41392-020-0149-3. PMID: 32382060; PMCID: PMC7205607. 8: Dou B, Hu W, Song M, Lee RJ, Zhang X, Wang D. Anti-inflammation of Erianin in dextran sulphate sodium-induced ulcerative colitis mice model via collaborative regulation of TLR4 and STAT3. Chem Biol Interact. 2020 Jun 1;324:109089. doi: 10.1016/j.cbi.2020.109089. Epub 2020 Apr 6. PMID: 32272095. 9: Mo C, Lu L, Liu D, Wei K. Development of erianin-loaded dendritic mesoporous silica nanospheres with pro-apoptotic effects and enhanced topical delivery. J Nanobiotechnology. 2020 Mar 30;18(1):55. doi: 10.1186/s12951-020-00608-3. PMID: 32228604; PMCID: PMC7104482. 10: Yi X, Lan X. LC-MS/MS method for the determination of erianin in rat plasma: Application to a pharmacokinetic study. Biomed Chromatogr. 2020 Jul;34(7):e4826. doi: 10.1002/bmc.4826. Epub 2020 Mar 30. PMID: 32163178. 11: Peng LQ, Dong X, Zhen XT, Yang J, Chen Y, Wang SL, Xie T, Cao J. Simultaneous separation and concentration of neutral analytes by cyclodextrin assisted sweeping-micellar electrokinetic chromatography. Anal Chim Acta. 2020 Apr 8;1105:224-230. doi: 10.1016/j.aca.2020.01.037. Epub 2020 Jan 22. PMID: 32138922. 12: Chen YT, Hsieh MJ, Chen PN, Weng CJ, Yang SF, Lin CW. Erianin Induces Apoptosis and Autophagy in Oral Squamous Cell Carcinoma Cells. Am J Chin Med. 2020;48(1):183-200. doi: 10.1142/S0192415X2050010X. Epub 2020 Jan 6. PMID: 31903779. 13: Zhang X, Wang Y, Li X, Yang A, Li Z, Wang D. The anti-carcinogenesis properties of erianin in the modulation of oxidative stress-mediated apoptosis and immune response in liver cancer. Aging (Albany NY). 2019 Nov 20;11(22):10284-10300. doi: 10.18632/aging.102456. Epub 2019 Nov 20. PMID: 31754081; PMCID: PMC6914393. 14: Liu N, Wang X, Liu H, Zhang C. Identification of the metabolites of erianin in rat and human by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2020 Apr 15;34(7):e8661. doi: 10.1002/rcm.8661. PMID: 31732995. 15: Zhang Y, Zhang Q, Wei F, Liu N. Progressive study of effects of erianin on anticancer activity. Onco Targets Ther. 2019 Jul 9;12:5457-5465. doi: 10.2147/OTT.S200161. PMID: 31371985; PMCID: PMC6628150. 16: Zhang T, Ouyang H, Mei X, Lu B, Yu Z, Chen K, Wang Z, Ji L. Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglial cells via inhibiting hyperglycemia-mediated ERK1/2-NF-κB signaling pathway. FASEB J. 2019 Nov;33(11):11776-11790. doi: 10.1096/fj.201802614RRR. Epub 2019 Jul 31. PMID: 31365278; PMCID: PMC6902687. 17: Mo C, Shetti D, Wei K. Erianin Inhibits Proliferation and Induces Apoptosis of HaCaT Cells via ROS-Mediated JNK/c-Jun and AKT/mTOR Signaling Pathways. Molecules. 2019 Jul 26;24(15):2727. doi: 10.3390/molecules24152727. PMID: 31357564; PMCID: PMC6695952. 18: Yuan W, Su C, Yang X, Li Y, Cao Y, Liang X, Liu J. Biological and anti- vascular activity evaluation of ethoxy-erianin phosphate as a vascular disrupting agent. J Cell Biochem. 2019 Oct;120(10):16978-16989. doi: 10.1002/jcb.28959. Epub 2019 May 20. PMID: 31111562. 19: Zhu Q, Sheng Y, Li W, Wang J, Ma Y, Du B, Tang Y. Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits bladder cancer cell growth via the mitochondrial apoptosis and JNK pathways. Toxicol Appl Pharmacol. 2019 May 15;371:41-54. doi: 10.1016/j.taap.2019.03.027. Epub 2019 Apr 1. PMID: 30946863. 20: Liu H, Mu D, Lin T, Li Q. A Simple Method for the Screening and Measurement of Phenols in Dendrobium chrysotoxum by a Miniature Mass Detector Using a Matrix Solid-Phase Dispersion Method. J Anal Methods Chem. 2019 Jan 23;2019:6737632. doi: 10.1155/2019/6737632. PMID: 30809414; PMCID: PMC6364100.

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